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Structure/function relationships underlying regulation of FOXO transcription factors
T Obsil, V Obsilova
Language English Country Great Britain
Document type Review
NLK
ProQuest Central
from 2000-01-01 to 1 year ago
Open Access Digital Library
from 1997-01-01
Medline Complete (EBSCOhost)
from 1997-01-09 to 2015-11-26
Health & Medicine (ProQuest)
from 2000-01-01 to 1 year ago
Public Health Database (ProQuest)
from 2000-01-01 to 1 year ago
- MeSH
- Acetylation MeSH
- Financing, Organized MeSH
- Forkhead Transcription Factors physiology chemistry MeSH
- Phosphorylation MeSH
- Protein Conformation MeSH
- Humans MeSH
- Protein Processing, Post-Translational MeSH
- Ubiquitin metabolism MeSH
- Structure-Activity Relationship MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Review MeSH
The FOXO subgroup of forkhead transcription factors plays a central role in cell-cycle control, differentiation, metabolism control, stress response and apoptosis. Therefore, the function of these important molecules is tightly controlled by a wide range of protein-protein interactions and posttranslational modifications including phosphorylation, acetylation and ubiquitination. The mechanisms by which these processes regulate FOXO activity are mostly elusive. This review focuses on recent advances in structural studies of forkhead transcription factors and the insights they provide into the mechanism of DNA recognition. On the basis of these data, we discuss structural aspects of protein-protein interactions and posttranslational modifications that target the forkhead domain and the nuclear localization signal of FOXO proteins.
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- $a Obšil, Tomáš, $d 1972- $7 uk2007304264
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- $a Structure/function relationships underlying regulation of FOXO transcription factors / $c T Obsil, V Obsilova
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- $a Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Prague, Czech Republic. obsil@natur.cuni.cz
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- $a The FOXO subgroup of forkhead transcription factors plays a central role in cell-cycle control, differentiation, metabolism control, stress response and apoptosis. Therefore, the function of these important molecules is tightly controlled by a wide range of protein-protein interactions and posttranslational modifications including phosphorylation, acetylation and ubiquitination. The mechanisms by which these processes regulate FOXO activity are mostly elusive. This review focuses on recent advances in structural studies of forkhead transcription factors and the insights they provide into the mechanism of DNA recognition. On the basis of these data, we discuss structural aspects of protein-protein interactions and posttranslational modifications that target the forkhead domain and the nuclear localization signal of FOXO proteins.
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- $a acetylace $7 D000107
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- $a zvířata $7 D000818
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- $a forkhead transkripční faktory $x fyziologie $x chemie $7 D051858
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- $a lidé $7 D006801
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- $a fosforylace $7 D010766
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- $a konformace proteinů $7 D011487
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- $a posttranslační úpravy proteinů $7 D011499
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- $a vztahy mezi strukturou a aktivitou $7 D013329
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- $a ubikvitin $x metabolismus $7 D025801
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- $a přehledy $7 D016454
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- $a Obšilová, Veronika, $d 1972- $7 xx0107730
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- $t Oncogene $w MED00003600 $g Roč. 27, č. 16 (2008), s. 2263-2275
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- $a 3
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- $a 2011-2B/ipme
