Numerous association studies have been involved in studying the angiotensinogen (AGT) variants, AGT plasma levels and relations to cardiovascular diseases, such as hypertension, myocardial infarction, coronary heart disease. To investigate a role of AGT G(-6)A and M235T genetic variants for chronic heart failure (CHF) and advanced atherosclerosis (AA), a total of 240 patients with CHF and 200 patients with AA of the Czech origin were evaluated for the study. The study shows the role of polymorphism AGT G(-6)A in genetic background among advanced atherosclerosis patients and chronic heart failure patients (Pg=0.001). This difference was also observed in comparison of AA patients with subgroup of CHF with dilated cardiomyopathy (Pg=0.02; Pa=0.009), and ischemic heart disease (Pg=0.007). The greatest difference between triple-vessel disease and chronic heart failure groups was observed in frequency of GT haplotype (P<0.001) and GGMT associated genotype (P<0.001). Retrospectively, we found the same trend when the subgroups of CHF were compared to AA group (AA vs. IHD with CHF P<0.001; AA vs. DCM P<0.001). These results suggest AGT genetic variants as a risk factor for chronic heart failure compared to advanced atherosclerosis disease without heart failure, with a strong difference between IHD patients and chronic heart failure patients with ischemic heart disease, especially in haplotypes and associated genotypes. PMID:20945963[PubMed - in process] Free Article LinkOut - more resourcesFull Text SourcesInstitute of Physiology, Academy of Sciences of the Czech Republic, Prague - PDFEBSCO • Supplemental Content Related citations Association of two angiotensinogen gene polymorphisms, M235T and G(-6)A, with chronic heart failure. [Int J Cardiol. 2003] Association of two angiotensinogen gene polymorphisms, M235T and G(-6)A, with chronic heart failure. Goldbergova M, Spinarova L, Spinar J, Toman J, Vasku A, Vacha J. Int J Cardiol. 2003 Jun; 89(2-3):267-72. Association between variants in the genes for leptin, leptin receptor, and proopiomelanocortin with chronic heart failure in the Czech population. [Heart Vessels. 2009] Association between variants in the genes for leptin, leptin receptor, and proopiomelanocortin with chronic heart failure in the Czech population. Bienertová-Vasků JA, Spinarová L, Bienert P, Vasků A. Heart Vessels. 2009 Mar; 24(2):131-7. Epub 2009 Apr 1.Angiotensinogen M235T polymorphism is associated with plasma angiotensinogen and cardiovascular disease. [Am Heart J. 1999] Angiotensinogen M235T polymorphism is associated with plasma angiotensinogen and cardiovascular disease. Winkelmann BR, Russ AP, Nauck M, Klein B, Böhm BO, Maier V, Zotz R, Matheis G, Wolf A, Wieland H, et al. Am Heart J. 1999 Apr; 137(4 Pt 1):698-705. Renin-angiotensin system gene polymorphisms: assessment of the risk of coronary heart disease. [Kardiol Pol. 2003] Renin-angiotensin system gene polymorphisms: assessment of the risk of coronary heart disease. Buraczyńska M, Pijanowski Z, Spasiewicz D, Nowicka T, Sodolski T, Widomska - Czekajska T, Ksiazek A. Kardiol Pol. 2003 Jan; 58(1):1-9. Review A haplotype of the angiotensinogen gene is associated with hypertension in african americans. [Clin Exp Pharmacol Physiol. 2005] Review A haplotype of the angiotensinogen gene is associated with hypertension in african americans. Kumar A, Li Y, Patil S, Jain S. Clin Exp Pharmacol Physiol. 2005 May-Jun; 32(5-6):495-502. See reviews... See all... All links from this record Related Citations Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.Gene Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.Gene (GeneRIF) Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.HomoloGene HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.Nucleotide Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.

Institute of Pathological Physiology Faculty of Medicine Masaryk University Brno Czech Republic

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