-
Je něco špatně v tomto záznamu ?
Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity
M. Michal, O. Hes, J. Němcová, R. Šíma, N. Kuroda, S. Bulimbasic, M. Franco, N. Sakaida, D. Daniš, D.V. Kazakov, C. Ohe, M. Hora
Jazyk angličtina Země Německo
Typ dokumentu kazuistiky
Grantová podpora
NS9722
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
Zdroj
NLK
ProQuest Central
od 2003-01-01 do Před 1 rokem
Nursing & Allied Health Database (ProQuest)
od 2003-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2003-01-01 do Před 1 rokem
- MeSH
- adenom chemicky indukované metabolismus patologie MeSH
- biologické markery metabolismus MeSH
- epitelové buňky patologie MeSH
- financování organizované MeSH
- keratin-20 metabolismus MeSH
- keratin-7 metabolismus MeSH
- keratiny metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- mucin 1 metabolismus MeSH
- mutace MeSH
- nádorový supresorový protein VHL genetika MeSH
- nádory ledvin genetika metabolismus patologie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- vimentin metabolismus MeSH
- ztráta heterozygozity MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
We present a series of a distinct tumorous entity named renal angiomyoadenomatous tumor (RAT). Five cases were retrieved from the consultation files of the authors. Histologic and immunohistochemical features were evaluated. Sequencing analysis of coding region of the VHL gene was carried out in all cases. The tumors were composed of admixture of an epithelial clear cell component and prominent leiomyomatous stroma. Epithelial cells formed adenomatous tubular formations endowed with blister-like apical snouts. All tubular/glandular structures were lined by a fine capillary network. The epithelial component was positive for epithelial membrane antigen, CK7, CK20, AE1-AE3, CAM5.2, and vimentin in all cases. In all analyzed samples, no mutation of the VHL gene was found. RAT is a distinct morphologic entity, being different morphologically, immunohistochemically, and genetically from all renal tumors including conventional clear cell carcinoma and mixed epithelial and stromal tumor of kidney.
Cytopathos s r o Bratislava Slovakia
Department of Pathology Charles University Faculty Hospital Plzen Czech Republic
Department of Pathology Kansai Medical University Hirakata Hospital Osaka Japan
Department of Urology Charles University Faculty Hospital Plzen Czech Republic
Citace poskytuje Crossref.org
- 000
- 03115naa 2200601 a 4500
- 001
- bmc11009908
- 003
- CZ-PrNML
- 005
- 20221005131046.0
- 008
- 110511s2009 gw e eng||
- 009
- AR
- 024 7_
- $a 10.1007/s00428-008-0697-3 $2 doi
- 035 __
- $a (PubMed)19020896
- 040 __
- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a gw
- 100 1_
- $a Michal, Michal, $d 1959- $7 jn20001103501 $u Department of Pathology, Charles University, Faculty Hospital, Plzen, Czech Republic; Sikl's Department of Pathology, Laboratore Spec. Diagnostiky Medical Faculty Hospital, Charles University, Plzen, Czech Republic
- 245 10
- $a Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity / $c M. Michal, O. Hes, J. Němcová, R. Šíma, N. Kuroda, S. Bulimbasic, M. Franco, N. Sakaida, D. Daniš, D.V. Kazakov, C. Ohe, M. Hora
- 314 __
- $a Department of Pathology, Charles University, Faculty Hospital, Plzen, Czech Republic. michal@medima.cz
- 520 9_
- $a We present a series of a distinct tumorous entity named renal angiomyoadenomatous tumor (RAT). Five cases were retrieved from the consultation files of the authors. Histologic and immunohistochemical features were evaluated. Sequencing analysis of coding region of the VHL gene was carried out in all cases. The tumors were composed of admixture of an epithelial clear cell component and prominent leiomyomatous stroma. Epithelial cells formed adenomatous tubular formations endowed with blister-like apical snouts. All tubular/glandular structures were lined by a fine capillary network. The epithelial component was positive for epithelial membrane antigen, CK7, CK20, AE1-AE3, CAM5.2, and vimentin in all cases. In all analyzed samples, no mutation of the VHL gene was found. RAT is a distinct morphologic entity, being different morphologically, immunohistochemically, and genetically from all renal tumors including conventional clear cell carcinoma and mixed epithelial and stromal tumor of kidney.
- 590 __
- $a bohemika - dle Pubmed
- 650 _2
- $a adenom $x chemicky indukované $x metabolismus $x patologie $7 D000236
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a senioři nad 80 let $7 D000369
- 650 _2
- $a biologické markery $x metabolismus $7 D015415
- 650 _2
- $a epitelové buňky $x patologie $7 D004847
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a keratin-20 $x metabolismus $7 D053554
- 650 _2
- $a keratin-7 $x metabolismus $7 D053552
- 650 _2
- $a keratiny $x metabolismus $7 D007633
- 650 _2
- $a nádory ledvin $x genetika $x metabolismus $x patologie $7 D007680
- 650 _2
- $a ztráta heterozygozity $7 D019656
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a mucin 1 $x metabolismus $7 D018396
- 650 _2
- $a mutace $7 D009154
- 650 _2
- $a vimentin $x metabolismus $7 D014746
- 650 _2
- $a nádorový supresorový protein VHL $x genetika $7 D051794
- 650 _2
- $a financování organizované $7 D005381
- 655 _2
- $a kazuistiky $7 D002363
- 700 1_
- $a Hes, Ondřej, $d 1968- $7 jn20001103502 $u Department of Pathology, Charles University, Faculty Hospital, Plzen, Czech Republic
- 700 1_
- $a Němcová, Jana. $7 xx0233246 $u Department of Pathology, Charles University, Faculty Hospital, Plzen, Czech Republic
- 700 1_
- $a Šíma, Radek $7 xx0118184 $u Department of Pathology, Charles University, Faculty Hospital, Plzen, Czech Republic
- 700 1_
- $a Kuroda, N. $u Red Cross Hospital Kochi, Kochi, Japan
- 700 1_
- $a Bulimbasic, S. $u University Hospital Dubrava, Zagreb, Croatia
- 700 1_
- $a Franco, M. $u EPM/UNIFESP, Sao Paulo, Brazil
- 700 1_
- $a Sakaida, N. $u Department of Pathology, Kansai Medical University Hirakata Hospital, Osaka, Japan
- 700 1_
- $a Daniš, Dušan $7 xx0063658 $u Cytopathos s.r.o., Bratislava, Slovakia
- 700 1_
- $a Kazakov, Dmitry V. $7 xx0127940 $u Department of Pathology, Charles University, Faculty Hospital, Plzen, Czech Republic
- 700 1_
- $a Ohe, C. $u Department of Pathology, Kansai Medical University Hirakata Hospital, Osaka, Japan
- 700 1_
- $a Hora, Milan, $d 1967- $7 mzk2004258359 $u Department of Urology, Charles University, Faculty Hospital, Plzen, Czech Republic
- 773 0_
- $t Virchows Archiv $w MED00004660 $g Roč. 454, č. 1 (2009), s. 89-99 $x 0945-6317
- 910 __
- $a ABA008 $b x $y 2 $z 0
- 990 __
- $a 20110513111517 $b ABA008
- 991 __
- $a 20221005131041 $b ABA008
- 999 __
- $a ok $b bmc $g 839197 $s 703313
- BAS __
- $a 3
- BMC __
- $a 2009 $b 454 $c 1 $d 89-99 $i 0945-6317 $m Virchows Archiv $n Virchows Arch $x MED00004660
- GRA __
- $a NS9722 $p MZ0
- LZP __
- $a 2011-2B09/jvme
