Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity
Language English Country Germany Media print-electronic
Document type Case Reports, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Adenoma genetics metabolism pathology MeSH
- Biomarkers metabolism MeSH
- Epithelial Cells pathology MeSH
- Keratin-20 metabolism MeSH
- Keratin-7 metabolism MeSH
- Keratins metabolism MeSH
- Middle Aged MeSH
- Humans MeSH
- Mucin-1 metabolism MeSH
- Mutation MeSH
- Von Hippel-Lindau Tumor Suppressor Protein genetics MeSH
- Kidney Neoplasms genetics metabolism pathology MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Vimentin metabolism MeSH
- Loss of Heterozygosity MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biomarkers MeSH
- CAM 5.2 antigen MeSH Browser
- Keratin-20 MeSH
- Keratin-7 MeSH
- Keratins MeSH
- Mucin-1 MeSH
- Von Hippel-Lindau Tumor Suppressor Protein MeSH
- VHL protein, human MeSH Browser
- Vimentin MeSH
We present a series of a distinct tumorous entity named renal angiomyoadenomatous tumor (RAT). Five cases were retrieved from the consultation files of the authors. Histologic and immunohistochemical features were evaluated. Sequencing analysis of coding region of the VHL gene was carried out in all cases. The tumors were composed of admixture of an epithelial clear cell component and prominent leiomyomatous stroma. Epithelial cells formed adenomatous tubular formations endowed with blister-like apical snouts. All tubular/glandular structures were lined by a fine capillary network. The epithelial component was positive for epithelial membrane antigen, CK7, CK20, AE1-AE3, CAM5.2, and vimentin in all cases. In all analyzed samples, no mutation of the VHL gene was found. RAT is a distinct morphologic entity, being different morphologically, immunohistochemically, and genetically from all renal tumors including conventional clear cell carcinoma and mixed epithelial and stromal tumor of kidney.
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