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Cytomegalovirus encephalitis/retinitis in allogeneic haematopoietic stem cell transplant recipient treated successfully with combination of cidofovir and foscarnet
P. Hubáček, P. Keslová, R. Formánková, P. Pochop, O. Cinek, M. Zajac, J. Lochmanová, J. Starý, P. Sedláček
Language English Country Denmark
Document type Case Reports, Research Support, Non-U.S. Gov't
NLK
Medline Complete (EBSCOhost)
from 1999-01-01 to 1 year ago
Wiley Online Library (archiv)
from 1999-01-01 to 2012-12-31
- MeSH
- Leukemia, Myeloid, Acute complications therapy MeSH
- Antiviral Agents therapeutic use MeSH
- Cytomegalovirus Infections etiology drug therapy complications MeSH
- Cytosine analogs & derivatives therapeutic use MeSH
- Encephalitis, Viral etiology drug therapy complications MeSH
- Foscarnet therapeutic use MeSH
- Humans MeSH
- Adolescent MeSH
- Organophosphonates therapeutic use MeSH
- Retinitis etiology drug therapy complications MeSH
- Hematopoietic Stem Cell Transplantation methods adverse effects MeSH
- Treatment Outcome MeSH
- Check Tag
- Humans MeSH
- Adolescent MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
- Research Support, Non-U.S. Gov't MeSH
We report an 18-yr-old female patient with repeated CMV reactivations after HSCT treated by several pre-emptive courses of virostatic therapy. Seven months after HSCT, she developed CMV encephalitis/retinitis. Initial therapy with GCV and hyperimmune globulin failed, and later on GCV-resistant strain was detected. Continual increase of CMV DNA in peripheral blood led us to combined therapy with CDV and FCV, which was successful and free of severe renal toxicity. To our best knowledge, this is the first reported case of successful CMV treatment with a combination of CDV and FCV.
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- $a Cytomegalovirus encephalitis/retinitis in allogeneic haematopoietic stem cell transplant recipient treated successfully with combination of cidofovir and foscarnet $c P. Hubáček, P. Keslová, R. Formánková, P. Pochop, O. Cinek, M. Zajac, J. Lochmanová, J. Starý, P. Sedláček
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- $a We report an 18-yr-old female patient with repeated CMV reactivations after HSCT treated by several pre-emptive courses of virostatic therapy. Seven months after HSCT, she developed CMV encephalitis/retinitis. Initial therapy with GCV and hyperimmune globulin failed, and later on GCV-resistant strain was detected. Continual increase of CMV DNA in peripheral blood led us to combined therapy with CDV and FCV, which was successful and free of severe renal toxicity. To our best knowledge, this is the first reported case of successful CMV treatment with a combination of CDV and FCV.
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