Melflufen for relapsed and refractory multiple myeloma
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, přehledy
- Klíčová slova
- Melflufen, melphalan flufenamide, relapsed/refractory multiple myeloma,
- MeSH
- alkylační protinádorové látky aplikace a dávkování škodlivé účinky farmakologie MeSH
- fenylalanin aplikace a dávkování škodlivé účinky analogy a deriváty farmakologie MeSH
- lidé MeSH
- melfalan aplikace a dávkování škodlivé účinky analogy a deriváty farmakologie MeSH
- míra přežití MeSH
- mnohočetný myelom farmakoterapie patologie MeSH
- protokoly protinádorové kombinované chemoterapie aplikace a dávkování škodlivé účinky farmakologie MeSH
- recidiva MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- alkylační protinádorové látky MeSH
- fenylalanin MeSH
- melfalan MeSH
- melflufen MeSH Prohlížeč
INTRODUCTION: The overall survival of patients with multiple myeloma has improved with the advent of novel agents; however, multiple myeloma remains incurable. Combinations of standard-of-care agents such as immunomodulators, proteasome inhibitors, and anti-CD38 monoclonal antibodies are increasingly used in earlier lines of therapy. Patients with disease that is refractory to multiple novel agents represent a population with high unmet medical need and for whom therapies with new mechanisms of action could be beneficial. Melphalan flufenamide (melflufen) has demonstrated encouraging activity in patients with relapsed and refractory multiple myeloma. AREAS COVERED: This review provides an overview of the mechanism of action of melflufen, a first-in-class peptide-drug conjugate that targets aminopeptidases and rapidly delivers alkylating agents into tumor cells. It reviews key Phase I and II clinical trial data for melflufen in combination with dexamethasone as well as in triplet combinations with daratumumab or bortezomib. The safety profile of melflufen, which is characterized primarily by clinically manageable hematologic adverse events, is described. EXPERT OPINION: Melflufen has potential to fill a gap in the myeloma treatment landscape by providing a new mechanism of action with clinically meaningful efficacy and a favorable safety profile in patients refractory to multiple novel agents.
Department of Hematology Clínica Universidad De Navarra Pamplona Spain
Department of Hematology Hôpital De La Milétrie CHU De Poitiers Poitiers France
Department of Medical Sciences Division of Clinical Pharmacology Uppsala University Uppsala Sweden
Myeloma Service Department of Medicine Memorial Sloan Kettering Cancer Center New York NY USA
Citace poskytuje Crossref.org