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Expansion of T helper type 17 lymphocytes in patients with chronic granulomatous disease
R. Horváth, D. Rožková, J. Lašťovička, A. Poloučková, P. Sedláček, A. Šedivá, R. Špíšek
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
NS10489
MZ0
CEP Register
Digital library NLK
Full text - Article
Source
NLK
Free Medical Journals
from 1966 to 1 year ago
PubMed Central
from 1966 to 1 year ago
Medline Complete (EBSCOhost)
from 1966-01-01 to 1 year ago
Wiley Online Library (archiv)
from 1990-01-01 to 2012-12-31
- MeSH
- Cell Differentiation immunology MeSH
- Th17 Cells immunology metabolism pathology MeSH
- Candida albicans growth & development MeSH
- Granulomatous Disease, Chronic genetics immunology metabolism pathology therapy MeSH
- Child MeSH
- Adult MeSH
- Enzyme-Linked Immunosorbent Assay MeSH
- Transplantation, Homologous MeSH
- Interferon-gamma immunology metabolism MeSH
- Interleukin-17 immunology metabolism MeSH
- Job Syndrome genetics immunology metabolism pathology MeSH
- Candidiasis immunology microbiology MeSH
- Humans MeSH
- Membrane Glycoproteins genetics immunology metabolism MeSH
- Mutation MeSH
- NADPH Oxidases genetics immunology metabolism MeSH
- Lymphocyte Count MeSH
- Child, Preschool MeSH
- Flow Cytometry MeSH
- Staphylococcal Infections immunology microbiology MeSH
- Staphylococcus aureus growth & development MeSH
- Case-Control Studies MeSH
- STAT3 Transcription Factor genetics immunology metabolism MeSH
- Hematopoietic Stem Cell Transplantation MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Humans MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Hyper-immunoglobulin (Ig)E syndrome (HIES) is a primary immunodeficiency associated with mutations in STAT3 resulting in impaired development of T helper type 17 (Th17) lymphocytes. HIES patients with a reduced frequency of Th17 cells present with infections caused by Staphylococcus aureus and/or Candida strains. The same spectrum of pathogens is present in patients with chronic granulomatous disease (CGD).We analysed the characteristics of the Th17 compartment in HIES and CGD. HIES patients showed very low numbers of Th17 cells. By contrast, the frequency of Th17 cells and production of Th17-derived cytokines was significantly higher among CGD patients when compared to both control samples and HIES. Naive CD4(+) cells in CGD patients had a normal capacity to differentiate into IL-17-producing cells and the numbers of Th17 cells in the CGD patients normalized following successful bone marrow transplantation. Our findings complement recent data on the importance of Th17 cells for elimination of infections with C. albicans and S. aureus.
References provided by Crossref.org
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