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Pregnancy-associated plasma protein A (PAPP-A) and soluble receptor for advanced glycation end products (sRAGE)--intra- and inter-individual variability in chronic hemodialysis patients
B. Míková, E. Jarolímková, H. Benáková, L. Dohnal, V. Tesař, T. Zima, M. Kalousová,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
NS10043
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
Plný text - Článek
Zdroj
NLK
Medline Complete (EBSCOhost)
od 1998-05-19 do Před 1 rokem
- MeSH
- analýza rozptylu MeSH
- biologické markery krev MeSH
- chronické selhání ledvin krev komplikace terapie MeSH
- dialýza ledvin MeSH
- kardiovaskulární nemoci krev etiologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- longitudinální studie MeSH
- počet leukocytů MeSH
- prospektivní studie MeSH
- receptory imunologické krev MeSH
- regresní analýza MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- těhotenský plazmatický protein A metabolismus MeSH
- transferin metabolismus MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
BACKGROUND: Dialysis patients are at high risk of cardiovascular complications. Pregnancy-associated plasma protein A (PAPP-A) as well as sRAGE (soluble receptor for advanced glycation end products) are new biomarkers related to cardiovascular disease. The aim of our study was to describe their intra- and inter-individual variability. METHODS: The studied group consisted of 21 chronic hemodialysis patients. PAPP-A, sRAGE and selected routine parameters were measured monthly during a 1-year prospective study. RESULTS: Our results show high intra-individual variability of both PAPP-A and sRAGE. Both PAPP-A and sRAGE were closely linked to serum transferrin levels. Additionally, sRAGE was significantly associated with leukocyte count and haemoglobin. CONCLUSION: Our study demonstrates high intra-individual variability of PAPP-A and sRAGE in stable clinical status. This finding could be helpful for further evaluation of the significance of PAPP-A and sRAGE in chronic kidney disease.
Citace poskytuje Crossref.org
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