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Microtubule disruptors and their interaction with biotransformation enzymes
M. Modrianský, Z. Dvorák
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
NLK
Directory of Open Access Journals
od 2001
Free Medical Journals
od 1998
ROAD: Directory of Open Access Scholarly Resources
od 2001
PubMed
16601758
DOI
10.5507/bp.2005.028
Knihovny.cz E-zdroje
- MeSH
- antimitotika farmakologie MeSH
- biotransformace MeSH
- kolchicin farmakologie MeSH
- lékové interakce MeSH
- lidé MeSH
- mikrotubuly účinky léků MeSH
- nokodazol farmakologie MeSH
- paclitaxel farmakologie MeSH
- receptory aromatických uhlovodíků metabolismus MeSH
- receptory glukokortikoidů metabolismus MeSH
- signální transdukce MeSH
- systém (enzymů) cytochromů P-450 metabolismus MeSH
- vinblastin farmakologie MeSH
- vinkristin farmakologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
Microtubule disruptors, widely known as antimitotics, have broad applications in human medicine, especially as anti-neoplastic agents. They are subject to biotransformation within human body frequently involving cytochromes P450. Therefore antimitotics are potential culprits of drug-drug interactions on the level of activity as well as expression of cytochromes P450. This review discusses the effects of four well-known natural antimitotics: colchicine, taxol (paclitaxel), vincristine, and vinblastine, and a synthetic microtubule disruptor nocodazole on transcriptional activity of glucocorticoid and aryl hydrocarbon receptors. It appears that microtubules disarray restricts the signaling by these two nuclear receptors regardless of cell cycle phase. Consequently, intact microtubules play an important role in the regulation of expression of cytochromes P450, which are under direct or indirect control of the two nuclear receptors.
Citace poskytuje Crossref.org
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