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Circulating cytokine pattern and factors describing rheumatoid arthritis: IL-15 as one of the biomarkers for RA?
M. Pavkova Goldbergova, N. Pavek, J. Lipkova, J. Jarkovsky, M. Stouracova, J. Gatterova, A. Vasku, M. Soucek, P. Nemec,
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Autoantibodies blood MeSH
- Biomarkers blood MeSH
- Peptides, Cyclic immunology MeSH
- Cytokines blood MeSH
- Adult MeSH
- Interleukin-15 blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Disease Progression MeSH
- Arthritis, Rheumatoid blood immunology radiography MeSH
- ROC Curve MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Case-Control Studies MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The aim of study was to examine relationship among levels of cytokines (IL-6, IL-13, IL-15, TNF-α) and chemokine (IL-8), production of autoantibodies, radiographic progression, and factors describing rheumatoid arthritis (RA). A total of 156 RA patients according to ACR criteria, and 55 control subjects were recruited into study. We observed higher levels of IL-15 within RA patients compared to healthy controls. Correlations among cytokine levels and the measures of rheumatoid factors, anti-CCP, measures of disease activity, and radiographic progression were observed. We conclude that IL-15 level in circulation could serve as one of the biomarkers for RA detection.
References provided by Crossref.org
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