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Biochemical and biophysical aspects of collagen nanostructure in the extracellular matrix

L. Kolácná, J. Bakesová, F. Varga, E. Kostáková, L. Plánka, A. Necas, D. Lukás, E. Amler, V. Pelouch

. 2007 ; 56 (Suppl 1) : S51-S60.
. 2007 ; 56 (Suppl 1) : S51-S60.

Language English Country Czech Republic

Document type Journal Article, Research Support, Non-U.S. Gov't, Review

Persistent link   https://www.medvik.cz/link/bmc13034083

ECM is composed of different collagenous and non-collagenous proteins. Collagen nanofibers play a dominant role in maintaining the biological and structural integrity of various tissues and organs, including bone, skin, tendon, blood vessels, and cartilage. Artificial collagen nanofibers are increasingly significant in numerous tissue engineering applications and seem to be ideal scaffolds for cell growth and proliferation. The modern tissue engineering task is to develop three-dimensional scaffolds of appropriate biological and biomechanical properties, at the same time mimicking the natural extracellular matrix and promoting tissue regeneration. Furthermore, it should be biodegradable, bioresorbable and non-inflammatory, should provide sufficient nutrient supply and have appropriate viscoelasticity and strength. Attributed to collagen features mentioned above, collagen fibers represent an obvious appropriate material for tissue engineering scaffolds. The aim of this minireview is, besides encapsulation of the basic biochemical and biophysical properties of collagen, to summarize the most promising modern methods and technologies for production of collagen nanofibers and scaffolds for artificial tissue development.

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$a Biochemical and biophysical aspects of collagen nanostructure in the extracellular matrix / $c L. Kolácná, J. Bakesová, F. Varga, E. Kostáková, L. Plánka, A. Necas, D. Lukás, E. Amler, V. Pelouch
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$a ECM is composed of different collagenous and non-collagenous proteins. Collagen nanofibers play a dominant role in maintaining the biological and structural integrity of various tissues and organs, including bone, skin, tendon, blood vessels, and cartilage. Artificial collagen nanofibers are increasingly significant in numerous tissue engineering applications and seem to be ideal scaffolds for cell growth and proliferation. The modern tissue engineering task is to develop three-dimensional scaffolds of appropriate biological and biomechanical properties, at the same time mimicking the natural extracellular matrix and promoting tissue regeneration. Furthermore, it should be biodegradable, bioresorbable and non-inflammatory, should provide sufficient nutrient supply and have appropriate viscoelasticity and strength. Attributed to collagen features mentioned above, collagen fibers represent an obvious appropriate material for tissue engineering scaffolds. The aim of this minireview is, besides encapsulation of the basic biochemical and biophysical properties of collagen, to summarize the most promising modern methods and technologies for production of collagen nanofibers and scaffolds for artificial tissue development.
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$a Bakešová, J. $u Department of Medical Chemistry and Biochemistry, Second Faculty of Medicine, Charles University, Prague $7 _AN075338
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$a Varga, Ferdinand, $u Institute of Biophysics, Second Faculty of Medicine, Charles University, Prague $d 1978- $7 mzk2007394831
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