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Association analysis of anti-inflammatory cytokine genes with the development of atopic allergic rhinitis
Vasila Alieva
Jazyk angličtina Země Česko
- MeSH
- alely MeSH
- celoroční alergická rýma * genetika MeSH
- chemokin CCL5 genetika MeSH
- cytokiny * genetika MeSH
- genetické markery MeSH
- genotyp MeSH
- lidé MeSH
- mutace MeSH
- polymorfismus genetický MeSH
- riziko MeSH
- sezónní alergická rýma * genetika MeSH
- studie případů a kontrol MeSH
- TNF-alfa genetika MeSH
- Check Tag
- lidé MeSH
- Geografické názvy
- Uzbekistán MeSH
Molecular analysis of occurrence frequencies of RANTES, TNF-a genetic markers among 44 allergic rhinitis patients was conducted. The frequency of “adverse allele” polymorphism TNF-a in observed general groups and in control group had basically no difference. However, during the comparative analysis, reliable association of RANTES genetic marker allele variants with the development of AR was discovered in general group. Besides, for the first time, intergenic interaction of polymorphous variant of cytokine genes “RANTES TNF-a” in determination of development risk of AR (OR=11.7, p<0.05) was established.
Citace poskytuje Crossref.org
Literatura
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- $a Molecular analysis of occurrence frequencies of RANTES, TNF-a genetic markers among 44 allergic rhinitis patients was conducted. The frequency of “adverse allele” polymorphism TNF-a in observed general groups and in control group had basically no difference. However, during the comparative analysis, reliable association of RANTES genetic marker allele variants with the development of AR was discovered in general group. Besides, for the first time, intergenic interaction of polymorphous variant of cytokine genes “RANTES TNF-a” in determination of development risk of AR (OR=11.7, p<0.05) was established.
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