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Association analysis of anti-inflammatory cytokine genes with the development of atopic allergic rhinitis
Vasila Alieva
Language English Country Czech Republic
- MeSH
- Alleles MeSH
- Rhinitis, Allergic, Perennial * genetics MeSH
- Chemokine CCL5 genetics MeSH
- Cytokines * genetics MeSH
- Genetic Markers MeSH
- Genotype MeSH
- Humans MeSH
- Mutation MeSH
- Polymorphism, Genetic MeSH
- Risk MeSH
- Rhinitis, Allergic, Seasonal * genetics MeSH
- Case-Control Studies MeSH
- Tumor Necrosis Factor-alpha genetics MeSH
- Check Tag
- Humans MeSH
- Geographicals
- Uzbekistan MeSH
Molecular analysis of occurrence frequencies of RANTES, TNF-a genetic markers among 44 allergic rhinitis patients was conducted. The frequency of “adverse allele” polymorphism TNF-a in observed general groups and in control group had basically no difference. However, during the comparative analysis, reliable association of RANTES genetic marker allele variants with the development of AR was discovered in general group. Besides, for the first time, intergenic interaction of polymorphous variant of cytokine genes “RANTES TNF-a” in determination of development risk of AR (OR=11.7, p<0.05) was established.
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Literatura
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- $a Molecular analysis of occurrence frequencies of RANTES, TNF-a genetic markers among 44 allergic rhinitis patients was conducted. The frequency of “adverse allele” polymorphism TNF-a in observed general groups and in control group had basically no difference. However, during the comparative analysis, reliable association of RANTES genetic marker allele variants with the development of AR was discovered in general group. Besides, for the first time, intergenic interaction of polymorphous variant of cytokine genes “RANTES TNF-a” in determination of development risk of AR (OR=11.7, p<0.05) was established.
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