-
Je něco špatně v tomto záznamu ?
HI-6 modulates immunization efficacy in a BALB/c mouse model
M. Pohanka,
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- adjuvancia imunologická farmakologie MeSH
- antidota farmakologie MeSH
- ELISA MeSH
- Freundovo adjuvans MeSH
- hemokyanin imunologie MeSH
- imunita účinky léků MeSH
- imunizace * MeSH
- interleukin-6 analýza biosyntéza MeSH
- myši inbrední BALB C MeSH
- myši MeSH
- oximy farmakologie MeSH
- protilátky analýza MeSH
- pyridinové sloučeniny farmakologie MeSH
- rovnováha Th1-Th2 účinky léků MeSH
- tvorba protilátek účinky léků MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
HI-6 is used as an antidote to nerve agents. It can also act as an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α 7 nAChR which is involved in regulating the immune response through macrophages. This experiment investigated the efficacy of HI-6 to regulate the immune response. Laboratory BALB/c mice received HI-6 and/or keyhole limpet hemocyanin (KLH) as an antigen. Antibody production was investigated after either 21 or 65 days when either single or repeated dose of antigen was applied. We confirmed that HI-6 significantly improved vaccination efficacy when KLH was given in a dose of 1mg/kg. The effect was dose dependent. A combination of HI-6 and KLH produced a vaccination of almost the same efficacy as that for Freund's complete adjuvant. The findings point at the suitability of HI-6 for improving vaccination efficacy at the level of immunity regulation by the nervous system.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc14074688
- 003
- CZ-PrNML
- 005
- 20141008093845.0
- 007
- ta
- 008
- 141006s2013 ne f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.etap.2013.07.012 $2 doi
- 035 __
- $a (PubMed)23958973
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ne
- 100 1_
- $a Pohanka, Miroslav $u Faculty of Military Health Sciences, University of Defense, Trebesska 1575, 50001 Hradec Kralove, Czech Republic; Karel Englis College in Brno, Sujanovo namesti 356/1, 60200 Brno, Czech Republic. Electronic address: miroslav.pohanka@gmail.com.
- 245 10
- $a HI-6 modulates immunization efficacy in a BALB/c mouse model / $c M. Pohanka,
- 520 9_
- $a HI-6 is used as an antidote to nerve agents. It can also act as an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α 7 nAChR which is involved in regulating the immune response through macrophages. This experiment investigated the efficacy of HI-6 to regulate the immune response. Laboratory BALB/c mice received HI-6 and/or keyhole limpet hemocyanin (KLH) as an antigen. Antibody production was investigated after either 21 or 65 days when either single or repeated dose of antigen was applied. We confirmed that HI-6 significantly improved vaccination efficacy when KLH was given in a dose of 1mg/kg. The effect was dose dependent. A combination of HI-6 and KLH produced a vaccination of almost the same efficacy as that for Freund's complete adjuvant. The findings point at the suitability of HI-6 for improving vaccination efficacy at the level of immunity regulation by the nervous system.
- 650 _2
- $a adjuvancia imunologická $x farmakologie $7 D000276
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a protilátky $x analýza $7 D000906
- 650 _2
- $a tvorba protilátek $x účinky léků $7 D000917
- 650 _2
- $a antidota $x farmakologie $7 D000931
- 650 _2
- $a vztah mezi dávkou a účinkem léčiva $7 D004305
- 650 _2
- $a ELISA $7 D004797
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a Freundovo adjuvans $7 D005620
- 650 _2
- $a hemokyanin $x imunologie $7 D006433
- 650 _2
- $a imunita $x účinky léků $7 D007109
- 650 12
- $a imunizace $7 D007114
- 650 _2
- $a interleukin-6 $x analýza $x biosyntéza $7 D015850
- 650 _2
- $a myši $7 D051379
- 650 _2
- $a myši inbrední BALB C $7 D008807
- 650 _2
- $a oximy $x farmakologie $7 D010091
- 650 _2
- $a pyridinové sloučeniny $x farmakologie $7 D011726
- 650 _2
- $a rovnováha Th1-Th2 $x účinky léků $7 D058408
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 773 0_
- $w MED00008557 $t Environmental toxicology and pharmacology $x 1872-7077 $g Roč. 36, č. 3 (2013), s. 801-6
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/23958973 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20141006 $b ABA008
- 991 __
- $a 20141008094233 $b ABA008
- 999 __
- $a ok $b bmc $g 1042571 $s 873600
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2013 $b 36 $c 3 $d 801-6 $i 1872-7077 $m Environmental toxicology and pharmacology $n Environ. toxicol. pharmacol. $x MED00008557
- LZP __
- $a Pubmed-20141006
