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MiRNA: Od biogeneze po využití v lékařství
[MiRNA: From biogenesis to medical utilization]

Veronika Vlahová, Kristýna Šmerková, Markéta Vaculovičová, René Kizek

. 2014 ; 1 (1) : 18-22.

Language Czech Country Czech Republic

Document type Research Support, Non-U.S. Gov't, Review

Persistent link   https://www.medvik.cz/link/bmc15013163

MicroRNAs are small non-coding RNA molecules that are involved in post-transcriptional regulation of gene expression. They take up about 2 % of the genome and affects up to one third of the protein-coding genes. Their biogenesis starts in the cell nucleus and passes into the cytoplasm where the functional forms of miRNAs participate in the process of RNA interference. Nowadays, the biggest interest focuses on the role of miRNAs during carcinogenesis. Mutations in the genes for various miRNAs types is to promote proliferation and inhibition of apoptosis. Therefore, the miRNA counts as a good diagnostic marker or even as a treatment method.

MiRNA: From biogenesis to medical utilization

Bibliography, etc.

Literatura

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