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Doxorubicin: pomoc i hrozba v léčbě rakoviny
[Doxorubicin: help and threat in cancer therapy]
Romana Konečná, Markéta Vaculovičová, Vojtěch Adam, René Kizek
Jazyk čeština Země Česko
Typ dokumentu práce podpořená grantem, přehledy
NLK
Open Access Digital Library
od 2014-01-01
- Klíčová slova
- stealth, enkapsulace,
- MeSH
- cytostatické látky farmakokinetika farmakologie škodlivé účinky MeSH
- doxorubicin * farmakokinetika farmakologie škodlivé účinky MeSH
- lékové transportní systémy * metody MeSH
- lidé MeSH
- liposomy metabolismus MeSH
- nádory farmakoterapie MeSH
- nemoci jater etiologie MeSH
- nemoci srdce chemicky indukované MeSH
- nežádoucí účinky léčiv * prevence a kontrola MeSH
- polyethylenglykoly MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- práce podpořená grantem MeSH
- přehledy MeSH
This article is focused on reviewing the benefit and limitations of utilization of doxorubicin, which is one of the most widely used anticancer drug even though it causes severe side effects. The mechanism of action of common cytostatic drugs is described and special attention is paid to doxorubicin. Its pathway through the body is highlighted and its toxicity is emphasized. Finally, strategy of elimination of the negative effects induced by doxorubicin therapy is mentioned and the most widely approach – the use of liposomes – is summarized.
Central European Institute of Technology Brno University of Technology
Department of Chemistry and Biochemistry Faculty of Agronomy Mendel University in Brno
Doxorubicin: help and threat in cancer therapy
Literatura
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