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Doxorubicin: pomoc i hrozba v léčbě rakoviny
[Doxorubicin: help and threat in cancer therapy]
Romana Konečná, Markéta Vaculovičová, Vojtěch Adam, René Kizek
Language Czech Country Czech Republic
Document type Research Support, Non-U.S. Gov't, Review
NLK
Open Access Digital Library
from 2014-01-01
- Keywords
- stealth, enkapsulace,
- MeSH
- Cytostatic Agents pharmacokinetics pharmacology adverse effects MeSH
- Doxorubicin * pharmacokinetics pharmacology adverse effects MeSH
- Drug Delivery Systems * methods MeSH
- Humans MeSH
- Liposomes metabolism MeSH
- Neoplasms drug therapy MeSH
- Liver Diseases etiology MeSH
- Heart Diseases chemically induced MeSH
- Drug-Related Side Effects and Adverse Reactions * prevention & control MeSH
- Polyethylene Glycols MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
This article is focused on reviewing the benefit and limitations of utilization of doxorubicin, which is one of the most widely used anticancer drug even though it causes severe side effects. The mechanism of action of common cytostatic drugs is described and special attention is paid to doxorubicin. Its pathway through the body is highlighted and its toxicity is emphasized. Finally, strategy of elimination of the negative effects induced by doxorubicin therapy is mentioned and the most widely approach – the use of liposomes – is summarized.
Central European Institute of Technology Brno University of Technology
Department of Chemistry and Biochemistry Faculty of Agronomy Mendel University in Brno
Doxorubicin: help and threat in cancer therapy
Literatura
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