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Excess NF-κB induces ectopic odontogenesis in embryonic incisor epithelium
J. Blackburn, K. Kawasaki, T. Porntaveetus, M. Kawasaki, Y. Otsuka-Tanaka, Y. Miake, MS. Ota, M. Watanabe, M. Hishinuma, T. Nomoto, S. Oommen, S. Ghafoor, F. Harada, K. Nozawa-Inoue, T. Maeda, R. Peterková, H. Lesot, J. Inoue, T. Akiyama, R....
Journal of dental research.
2015 ;
94 (1) :
121-8.
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc15014010
PubMed
25376721
DOI
10.1177/0022034514556707
Knihovny.cz E-zdroje
- MeSH
- ameloblasty cytologie MeSH
- amelogenin analýza MeSH
- apoptóza fyziologie MeSH
- epitel embryologie MeSH
- fenotyp MeSH
- keratin-15 genetika MeSH
- kinasa I-kappa B fyziologie MeSH
- kostní morfogenetické proteiny genetika MeSH
- mikroradiografie metody MeSH
- mutace genetika MeSH
- mutantní kmeny myší MeSH
- myši MeSH
- NF-kappa B fyziologie MeSH
- odontogeneze fyziologie MeSH
- promotorové oblasti (genetika) genetika MeSH
- proteiny hedgehog fyziologie MeSH
- receptory buněčného povrchu fyziologie MeSH
- rentgenová mikrotomografie metody MeSH
- řezáky abnormality embryologie MeSH
- signální dráha Wnt genetika fyziologie MeSH
- zobrazování trojrozměrné metody MeSH
- zubní sklovina cytologie MeSH
- zubní zárodek abnormality embryologie MeSH
- zuby přespočetné etiologie genetika MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Nuclear factor kappa B (NF-κB) signaling plays critical roles in many physiological and pathological processes, including regulating organogenesis. Down-regulation of NF-κB signaling during development results in hypohidrotic ectodermal dysplasia. The roles of NF-κB signaling in tooth development, however, are not fully understood. We examined mice overexpressing IKKβ, an essential component of the NF-κB pathway, under keratin 5 promoter (K5-Ikkβ). K5-Ikkβ mice showed supernumerary incisors whose formation was accompanied by up-regulation of canonical Wnt signaling. Apoptosis that is normally observed in wild-type incisor epithelium was reduced in K5-Ikkβ mice. The supernumerary incisors in K5-Ikkβ mice were found to phenocopy extra incisors in mice with mutations of Wnt inhibitor, Wise. Excess NF-κB activity thus induces an ectopic odontogenesis program that is usually suppressed under physiological conditions.
Department of Special Needs Dentistry Nihon University School of Dentistry at Matsudo Matsudo Japan
Department of Ultrastructural Science Tokyo Dental College Chiyoda ku Tokyo Japan
Citace poskytuje Crossref.org
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- $a Nuclear factor kappa B (NF-κB) signaling plays critical roles in many physiological and pathological processes, including regulating organogenesis. Down-regulation of NF-κB signaling during development results in hypohidrotic ectodermal dysplasia. The roles of NF-κB signaling in tooth development, however, are not fully understood. We examined mice overexpressing IKKβ, an essential component of the NF-κB pathway, under keratin 5 promoter (K5-Ikkβ). K5-Ikkβ mice showed supernumerary incisors whose formation was accompanied by up-regulation of canonical Wnt signaling. Apoptosis that is normally observed in wild-type incisor epithelium was reduced in K5-Ikkβ mice. The supernumerary incisors in K5-Ikkβ mice were found to phenocopy extra incisors in mice with mutations of Wnt inhibitor, Wise. Excess NF-κB activity thus induces an ectopic odontogenesis program that is usually suppressed under physiological conditions.
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