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Excess NF-κB induces ectopic odontogenesis in embryonic incisor epithelium
J. Blackburn, K. Kawasaki, T. Porntaveetus, M. Kawasaki, Y. Otsuka-Tanaka, Y. Miake, MS. Ota, M. Watanabe, M. Hishinuma, T. Nomoto, S. Oommen, S. Ghafoor, F. Harada, K. Nozawa-Inoue, T. Maeda, R. Peterková, H. Lesot, J. Inoue, T. Akiyama, R....
Journal of dental research.
2015 ;
94 (1) :
121-8.
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
Persistent link
https://www.medvik.cz/link/bmc15014010
- MeSH
- Ameloblasts cytology MeSH
- Amelogenin analysis MeSH
- Apoptosis physiology MeSH
- Epithelium embryology MeSH
- Phenotype MeSH
- Keratin-15 genetics MeSH
- I-kappa B Kinase physiology MeSH
- Bone Morphogenetic Proteins genetics MeSH
- Microradiography methods MeSH
- Mutation genetics MeSH
- Mice, Mutant Strains MeSH
- Mice MeSH
- NF-kappa B physiology MeSH
- Odontogenesis physiology MeSH
- Promoter Regions, Genetic genetics MeSH
- Hedgehog Proteins physiology MeSH
- Receptors, Cell Surface physiology MeSH
- X-Ray Microtomography methods MeSH
- Incisor abnormalities embryology MeSH
- Wnt Signaling Pathway genetics physiology MeSH
- Imaging, Three-Dimensional methods MeSH
- Dental Enamel cytology MeSH
- Tooth Germ abnormalities embryology MeSH
- Tooth, Supernumerary etiology genetics MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Nuclear factor kappa B (NF-κB) signaling plays critical roles in many physiological and pathological processes, including regulating organogenesis. Down-regulation of NF-κB signaling during development results in hypohidrotic ectodermal dysplasia. The roles of NF-κB signaling in tooth development, however, are not fully understood. We examined mice overexpressing IKKβ, an essential component of the NF-κB pathway, under keratin 5 promoter (K5-Ikkβ). K5-Ikkβ mice showed supernumerary incisors whose formation was accompanied by up-regulation of canonical Wnt signaling. Apoptosis that is normally observed in wild-type incisor epithelium was reduced in K5-Ikkβ mice. The supernumerary incisors in K5-Ikkβ mice were found to phenocopy extra incisors in mice with mutations of Wnt inhibitor, Wise. Excess NF-κB activity thus induces an ectopic odontogenesis program that is usually suppressed under physiological conditions.
Department of Special Needs Dentistry Nihon University School of Dentistry at Matsudo Matsudo Japan
Department of Ultrastructural Science Tokyo Dental College Chiyoda ku Tokyo Japan
References provided by Crossref.org
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- $a Nuclear factor kappa B (NF-κB) signaling plays critical roles in many physiological and pathological processes, including regulating organogenesis. Down-regulation of NF-κB signaling during development results in hypohidrotic ectodermal dysplasia. The roles of NF-κB signaling in tooth development, however, are not fully understood. We examined mice overexpressing IKKβ, an essential component of the NF-κB pathway, under keratin 5 promoter (K5-Ikkβ). K5-Ikkβ mice showed supernumerary incisors whose formation was accompanied by up-regulation of canonical Wnt signaling. Apoptosis that is normally observed in wild-type incisor epithelium was reduced in K5-Ikkβ mice. The supernumerary incisors in K5-Ikkβ mice were found to phenocopy extra incisors in mice with mutations of Wnt inhibitor, Wise. Excess NF-κB activity thus induces an ectopic odontogenesis program that is usually suppressed under physiological conditions.
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