-
Je něco špatně v tomto záznamu ?
A new twist in neuroendocrine tumor research: Pacak-Zhuang syndrome, HIF-2α as the major player in its pathogenesis and future therapeutic options
I. Jochmanova, I. Lazurova
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články, přehledy
NLK
Directory of Open Access Journals
od 2001
Free Medical Journals
od 1998
Medline Complete (EBSCOhost)
od 2007-06-01
ROAD: Directory of Open Access Scholarly Resources
od 2001
- MeSH
- karcinogeneze genetika MeSH
- lidé MeSH
- mutace MeSH
- paragangliom farmakoterapie genetika MeSH
- polycytemie vrozené farmakoterapie genetika MeSH
- somatostatinom farmakoterapie genetika MeSH
- syndrom MeSH
- transkripční faktory bHLH genetika MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
UNLABELLED: Backround. There is increasing evidence of the role of hypoxia or pseudohypoxia in tumorigenesis, including pheochromocytoma (PHEO) and paraganglioma (PGL). (Pseudo)hypoxia leads to activation of hypoxia-inducible transcription factors (HIFs) and thus, promotes the transcription of hypoxia-responsive genes which are involved in tumorigenesis. Recently identified is a new syndrome consisting of multiple and recurrent PGLs or PHEOs, somatostatinoma, and congenital polycythemia, due to somatic hypoxia-inducible factor 2α gene (HIF2A) mutations. METHODS AND RESULTS: PubMed and Web of Science online databases were used to search reviews and original articles on the HIF, PHEO/PGL, and Pacak-Zhuang syndrome. CONCLUSIONS: The novel somatic and germline gain-of-function HIF2A mutations described latterly emphasize the role of the HIF-2α in the PHEO/PGL development and these findings designate HIF, especially HIF-2α, as a promising treatment target.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc15033221
- 003
- CZ-PrNML
- 005
- 20151030145020.0
- 007
- ta
- 008
- 151016s2014 xr f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.5507/bp.2014.021 $2 doi
- 035 __
- $a (PubMed)24781045
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Jochmanová, Ivana. $u 1st Department of Internal Medicine, Medical Faculty, P.J. Safarik University, Kosice, Slovak Republic $7 xx0267304
- 245 12
- $a A new twist in neuroendocrine tumor research: Pacak-Zhuang syndrome, HIF-2α as the major player in its pathogenesis and future therapeutic options / $c I. Jochmanova, I. Lazurova
- 520 9_
- $a UNLABELLED: Backround. There is increasing evidence of the role of hypoxia or pseudohypoxia in tumorigenesis, including pheochromocytoma (PHEO) and paraganglioma (PGL). (Pseudo)hypoxia leads to activation of hypoxia-inducible transcription factors (HIFs) and thus, promotes the transcription of hypoxia-responsive genes which are involved in tumorigenesis. Recently identified is a new syndrome consisting of multiple and recurrent PGLs or PHEOs, somatostatinoma, and congenital polycythemia, due to somatic hypoxia-inducible factor 2α gene (HIF2A) mutations. METHODS AND RESULTS: PubMed and Web of Science online databases were used to search reviews and original articles on the HIF, PHEO/PGL, and Pacak-Zhuang syndrome. CONCLUSIONS: The novel somatic and germline gain-of-function HIF2A mutations described latterly emphasize the role of the HIF-2α in the PHEO/PGL development and these findings designate HIF, especially HIF-2α, as a promising treatment target.
- 650 _2
- $a transkripční faktory bHLH $x genetika $7 D051792
- 650 _2
- $a karcinogeneze $x genetika $7 D063646
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mutace $7 D009154
- 650 _2
- $a paragangliom $x farmakoterapie $x genetika $7 D010235
- 650 _2
- $a polycytemie $x vrozené $x farmakoterapie $x genetika $7 D011086
- 650 _2
- $a somatostatinom $x farmakoterapie $x genetika $7 D013005
- 650 _2
- $a syndrom $7 D013577
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Lazurová, Ivica $7 _AN084817 $u 1st Department of Internal Medicine, Medical Faculty, P.J. Safarik University, Kosice, Slovak Republic
- 773 0_
- $w MED00012606 $t Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic $x 1213-8118 $g Roč. 158, č. 2 (2014), s. 175-180
- 856 41
- $u http://biomed.papers.upol.cz/ $y domovská stránka časopisu
- 910 __
- $a ABA008 $b A 1502 $c 958 $y 4 $z 0
- 990 __
- $a 20151016 $b ABA008
- 991 __
- $a 20151029083153 $b ABA008
- 999 __
- $a ok $b bmc $g 1095623 $s 916352
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2014 $b 158 $c 2 $d 175-180 $e 20140429 $i 1213-8118 $m Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic $n Biomed. Pap. Fac. Med. Palacký Univ. Olomouc Czech Repub. (Print) $x MED00012606
- LZP __
- $b NLK118 $a Pubmed-20151016
