Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Safety of Statin Pretreatment in Intravenous Thrombolysis for Acute Ischemic Stroke

G. Tsivgoulis, P. Kadlecová, A. Kobayashi, A. Czlonkowska, M. Brozman, V. Švigelj, L. Csiba, J. Kõrv, V. Demarin, A. Vilionskis, D. Jatuzis, AH. Katsanos, J. Rudolf, Y. Krespi, R. Mikulik,

. 2015 ; 46 (9) : 2681-4. [pub] 20150714

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc16000089

BACKGROUND AND PURPOSE: A recent meta-analysis investigating the association between statins and early outcomes in acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) indicated that prestroke statin treatment was associated with increased risk of 90-day mortality and symptomatic intracranial hemorrhage. We investigated the potential association of statin pretreatment with early outcomes in a large, international registry of AIS patients treated with IVT. METHODS: We analyzed prospectively collected data from the Safe Implementation of Treatments in Stroke-East registry (SITS-EAST) registry on consecutive AIS patients treated with IVT during an 8-year period. Early clinical recovery within 24 hours was defined as reduction in baseline National Institutes of Health Stroke Scale score of ≥10 points. Favorable functional outcome at 3 months was defined as modified Rankin Scale scores of 0 to 1. Symptomatic intracranial hemorrhage was diagnosed using National Institute of Neurological Disorders and Stroke, European-Australasian Acute Stroke Study-II and SITS definitions. RESULTS: A total of 1660 AIS patients treated with IVT fulfilled our inclusion criteria. Patients with statin pretreatment (23%) had higher baseline stroke severity compared with cases who had not received any statin at symptom onset. After adjusting for potential confounders, statin pretreatment was not associated with a higher likelihood of symptomatic intracranial hemorrhage defined by any of the 3 definitions. Statin pretreatment was not related to 3-month all-cause mortality (odds ratio, 0.92; 95% confidence interval, 0.57-1.49; P=0.741) or 3-month favorable functional outcome (odds ratio, 0.81; 95% confidence interval, 0.52-1.27; P=0.364). Statin pretreatment was independently associated with a higher odds of early clinical recovery (odds ratio, 1.91; 95% confidence interval, 1.25-2.92; P=0.003). CONCLUSIONS: Statin pretreatment seems not to be associated with adverse outcomes in AIS patients treated with IVT. The effect of statin pretreatment on early functional outcomes in thrombolysed AIS patients deserves further investigation.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc16000089
003      
CZ-PrNML
005      
20160127114508.0
007      
ta
008      
160108s2015 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1161/STROKEAHA.115.010244 $2 doi
035    __
$a (PubMed)26173726
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Tsivgoulis, Georgios $u From the Second Department of Neurology, "Attikon" Hospital, University of Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of Neurology, International Clinical Research Center, St. Anne's Hospital, Brno, Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.); Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki, Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.). tsivgoulisgiorg@yahoo.gr.
245    10
$a Safety of Statin Pretreatment in Intravenous Thrombolysis for Acute Ischemic Stroke / $c G. Tsivgoulis, P. Kadlecová, A. Kobayashi, A. Czlonkowska, M. Brozman, V. Švigelj, L. Csiba, J. Kõrv, V. Demarin, A. Vilionskis, D. Jatuzis, AH. Katsanos, J. Rudolf, Y. Krespi, R. Mikulik,
520    9_
$a BACKGROUND AND PURPOSE: A recent meta-analysis investigating the association between statins and early outcomes in acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) indicated that prestroke statin treatment was associated with increased risk of 90-day mortality and symptomatic intracranial hemorrhage. We investigated the potential association of statin pretreatment with early outcomes in a large, international registry of AIS patients treated with IVT. METHODS: We analyzed prospectively collected data from the Safe Implementation of Treatments in Stroke-East registry (SITS-EAST) registry on consecutive AIS patients treated with IVT during an 8-year period. Early clinical recovery within 24 hours was defined as reduction in baseline National Institutes of Health Stroke Scale score of ≥10 points. Favorable functional outcome at 3 months was defined as modified Rankin Scale scores of 0 to 1. Symptomatic intracranial hemorrhage was diagnosed using National Institute of Neurological Disorders and Stroke, European-Australasian Acute Stroke Study-II and SITS definitions. RESULTS: A total of 1660 AIS patients treated with IVT fulfilled our inclusion criteria. Patients with statin pretreatment (23%) had higher baseline stroke severity compared with cases who had not received any statin at symptom onset. After adjusting for potential confounders, statin pretreatment was not associated with a higher likelihood of symptomatic intracranial hemorrhage defined by any of the 3 definitions. Statin pretreatment was not related to 3-month all-cause mortality (odds ratio, 0.92; 95% confidence interval, 0.57-1.49; P=0.741) or 3-month favorable functional outcome (odds ratio, 0.81; 95% confidence interval, 0.52-1.27; P=0.364). Statin pretreatment was independently associated with a higher odds of early clinical recovery (odds ratio, 1.91; 95% confidence interval, 1.25-2.92; P=0.003). CONCLUSIONS: Statin pretreatment seems not to be associated with adverse outcomes in AIS patients treated with IVT. The effect of statin pretreatment on early functional outcomes in thrombolysed AIS patients deserves further investigation.
650    _2
$a intravenózní podání $7 D061605
650    _2
$a senioři $7 D000368
650    _2
$a senioři nad 80 let $7 D000369
650    _2
$a ischemie mozku $x farmakoterapie $7 D002545
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a následné studie $7 D005500
650    _2
$a lidé $7 D006801
650    _2
$a statiny $x aplikace a dávkování $x škodlivé účinky $7 D019161
650    _2
$a intrakraniální krvácení $x chemicky indukované $7 D020300
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a mortalita $7 D009026
650    12
$a hodnocení výsledků zdravotní péče $7 D017063
650    12
$a registrace $7 D012042
650    _2
$a stupeň závažnosti nemoci $7 D012720
650    _2
$a cévní mozková příhoda $x farmakoterapie $7 D020521
650    _2
$a trombolytická terapie $x metody $7 D015912
651    _2
$a Evropa $7 D005060
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Kadlecová, Pavla $u From the Second Department of Neurology, "Attikon" Hospital, University of Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of Neurology, International Clinical Research Center, St. Anne's Hospital, Brno, Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.); Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki, Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
700    1_
$a Kobayashi, Adam $u From the Second Department of Neurology, "Attikon" Hospital, University of Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of Neurology, International Clinical Research Center, St. Anne's Hospital, Brno, Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.); Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki, Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
700    1_
$a Czlonkowska, Anna $u From the Second Department of Neurology, "Attikon" Hospital, University of Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of Neurology, International Clinical Research Center, St. Anne's Hospital, Brno, Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.); Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki, Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
700    1_
$a Brozman, Miroslav $u From the Second Department of Neurology, "Attikon" Hospital, University of Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of Neurology, International Clinical Research Center, St. Anne's Hospital, Brno, Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.); Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki, Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
700    1_
$a Švigelj, Viktor $u From the Second Department of Neurology, "Attikon" Hospital, University of Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of Neurology, International Clinical Research Center, St. Anne's Hospital, Brno, Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.); Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki, Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
700    1_
$a Csiba, Laszlo $u From the Second Department of Neurology, "Attikon" Hospital, University of Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of Neurology, International Clinical Research Center, St. Anne's Hospital, Brno, Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.); Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki, Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
700    1_
$a Kõrv, Janika $u From the Second Department of Neurology, "Attikon" Hospital, University of Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of Neurology, International Clinical Research Center, St. Anne's Hospital, Brno, Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.); Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki, Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
700    1_
$a Demarin, Vida $u From the Second Department of Neurology, "Attikon" Hospital, University of Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of Neurology, International Clinical Research Center, St. Anne's Hospital, Brno, Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.); Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki, Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
700    1_
$a Vilionskis, Aleksandras $u From the Second Department of Neurology, "Attikon" Hospital, University of Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of Neurology, International Clinical Research Center, St. Anne's Hospital, Brno, Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.); Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki, Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
700    1_
$a Jatuzis, Dalius $u From the Second Department of Neurology, "Attikon" Hospital, University of Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of Neurology, International Clinical Research Center, St. Anne's Hospital, Brno, Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.); Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki, Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
700    1_
$a Katsanos, Aristeidis H $u From the Second Department of Neurology, "Attikon" Hospital, University of Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of Neurology, International Clinical Research Center, St. Anne's Hospital, Brno, Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.); Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki, Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
700    1_
$a Rudolf, Jobst $u From the Second Department of Neurology, "Attikon" Hospital, University of Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of Neurology, International Clinical Research Center, St. Anne's Hospital, Brno, Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.); Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki, Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
700    1_
$a Krespi, Yakup $u From the Second Department of Neurology, "Attikon" Hospital, University of Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of Neurology, International Clinical Research Center, St. Anne's Hospital, Brno, Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.); Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki, Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
700    1_
$a Mikulik, Robert $u From the Second Department of Neurology, "Attikon" Hospital, University of Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of Neurology, International Clinical Research Center, St. Anne's Hospital, Brno, Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.); Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki, Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
773    0_
$w MED00010659 $t Stroke; a journal of cerebral circulation $x 1524-4628 $g Roč. 46, č. 9 (2015), s. 2681-4
856    41
$u https://pubmed.ncbi.nlm.nih.gov/26173726 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20160108 $b ABA008
991    __
$a 20160127114632 $b ABA008
999    __
$a ok $b bmc $g 1102370 $s 924295
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2015 $b 46 $c 9 $d 2681-4 $e 20150714 $i 1524-4628 $m Stroke $n Stroke $x MED00010659
LZP    __
$a Pubmed-20160108

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace