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Central role for ferritin in the day/night regulation of iron homeostasis in marine phytoplankton

H. Botebol, E. Lesuisse, R. Šuták, C. Six, JC. Lozano, P. Schatt, V. Vergé, A. Kirilovsky, J. Morrissey, T. Léger, JM. Camadro, A. Gueneugues, C. Bowler, S. Blain, FY. Bouget,

. 2015 ; 112 (47) : 14652-7. [pub] 20151109

Language English Country United States

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc16009909

In large regions of the open ocean, iron is a limiting resource for phytoplankton. The reduction of iron quota and the recycling of internal iron pools are among the diverse strategies that phytoplankton have evolved to allow them to grow under chronically low ambient iron levels. Phytoplankton species also have evolved strategies to cope with sporadic iron supply such as long-term storage of iron in ferritin. In the picophytoplanktonic species Ostreococcus we report evidence from observations both in the field and in laboratory cultures that ferritin and the main iron-binding proteins involved in photosynthesis and nitrate assimilation pathways show opposite diurnal expression patterns, with ferritin being maximally expressed during the night. Biochemical and physiological experiments using a ferritin knock-out line subsequently revealed that this protein plays a central role in the diel regulation of iron uptake and recycling and that this regulation of iron homeostasis is essential for cell survival under iron limitation.

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$a Botebol, Hugo $u Sorbonne Universités, University Pierre et Marie Curie, University of Paris VI, CNRS, Laboratoire d'Océanographie Microbienne, Observatoire Océanologique, F-66650, Banyuls-sur-Mer, France;
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$a Central role for ferritin in the day/night regulation of iron homeostasis in marine phytoplankton / $c H. Botebol, E. Lesuisse, R. Šuták, C. Six, JC. Lozano, P. Schatt, V. Vergé, A. Kirilovsky, J. Morrissey, T. Léger, JM. Camadro, A. Gueneugues, C. Bowler, S. Blain, FY. Bouget,
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$a In large regions of the open ocean, iron is a limiting resource for phytoplankton. The reduction of iron quota and the recycling of internal iron pools are among the diverse strategies that phytoplankton have evolved to allow them to grow under chronically low ambient iron levels. Phytoplankton species also have evolved strategies to cope with sporadic iron supply such as long-term storage of iron in ferritin. In the picophytoplanktonic species Ostreococcus we report evidence from observations both in the field and in laboratory cultures that ferritin and the main iron-binding proteins involved in photosynthesis and nitrate assimilation pathways show opposite diurnal expression patterns, with ferritin being maximally expressed during the night. Biochemical and physiological experiments using a ferritin knock-out line subsequently revealed that this protein plays a central role in the diel regulation of iron uptake and recycling and that this regulation of iron homeostasis is essential for cell survival under iron limitation.
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$a Lesuisse, Emmanuel $u Université Paris Diderot-Paris 7, CNRS, Institut Jacques Monod, F-75013 Paris, France;
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$a Six, Christophe $u Sorbonne Universités, University Pierre et Marie Curie, University of Paris VI, CNRS UMR 7144 Adaptation et Diversité en Milieux Marins, Marine Phototrophic Prokaryotes Group, Roscoff Biological Station, CS 90074, 29688 Roscoff cedex, France;
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$a Lozano, Jean-Claude $u Sorbonne Universités, University Pierre et Marie Curie, University of Paris VI, CNRS, Laboratoire d'Océanographie Microbienne, Observatoire Océanologique, F-66650, Banyuls-sur-Mer, France;
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$a Schatt, Philippe $u Sorbonne Universités, University Pierre et Marie Curie, University of Paris VI, CNRS, Laboratoire d'Océanographie Microbienne, Observatoire Océanologique, F-66650, Banyuls-sur-Mer, France;
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$a Vergé, Valérie $u Unité Mixte de Service, UMS2348, F-66651, Banyuls-sur-Mer, France;
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$a Kirilovsky, Amos $u Institut de Biologie de l'Ecole Normale Supérieure, CNRS UMR8197 Inserm U1024, 75005 Paris, France.
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$a Léger, Thibaut $u Université Paris Diderot-Paris 7, CNRS, Institut Jacques Monod, F-75013 Paris, France;
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$a Camadro, Jean-Michel $u Université Paris Diderot-Paris 7, CNRS, Institut Jacques Monod, F-75013 Paris, France;
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$a Gueneugues, Audrey $u Sorbonne Universités, University Pierre et Marie Curie, University of Paris VI, CNRS, Laboratoire d'Océanographie Microbienne, Observatoire Océanologique, F-66650, Banyuls-sur-Mer, France;
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$a Bowler, Chris $u Institut de Biologie de l'Ecole Normale Supérieure, CNRS UMR8197 Inserm U1024, 75005 Paris, France.
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$a Bouget, François-Yves $u Sorbonne Universités, University Pierre et Marie Curie, University of Paris VI, CNRS, Laboratoire d'Océanographie Microbienne, Observatoire Océanologique, F-66650, Banyuls-sur-Mer, France; blain@obs-banyuls.fr fy.bouget@obs-banyuls.fr.
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