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Impact of Inherited Prothrombotic Disorders on the Long-Term Clinical Outcome of Percutaneous Transluminal Angioplasty in Patients with Diabetes
M. Dubský, A. Jirkovská, L. Pagáčová, R. Bém, A. Němcová, V. Fejfarová, V. Wosková, EB. Jude,
Language English Country Egypt
Document type Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't
PubMed
26247037
DOI
10.1155/2015/369758
Knihovny.cz E-resources
- MeSH
- Angioplasty adverse effects MeSH
- Leg blood supply MeSH
- Point Mutation * MeSH
- Diabetic Angiopathies etiology physiopathology therapy MeSH
- Factor V analysis genetics MeSH
- Genetic Association Studies MeSH
- Ischemia epidemiology etiology prevention & control MeSH
- Middle Aged MeSH
- Humans MeSH
- Methylenetetrahydrofolate Reductase (NADPH2) blood genetics MeSH
- Arm blood supply MeSH
- Prevalence MeSH
- Prothrombin analysis genetics MeSH
- Cross-Sectional Studies MeSH
- Recurrence MeSH
- Aged MeSH
- Amino Acid Substitution MeSH
- Thrombophilia blood complications genetics physiopathology MeSH
- Thrombosis complications etiology physiopathology therapy MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Controlled Clinical Trial MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
The aim of our study was to analyse inherited thrombotic disorders that influence the long-term outcome of PTA. Methods. Diabetic patients with peripheral arterial disease (PAD) treated by PTA in our centre between 2008 and 2011 were included in the study. Patients were divided into unsuccessful PTA group (75 patients), successful PTA group (58 patients), and control group (65 patients, with diabetes but no PAD). Diagnosis of inherited thrombotic disorders included mutation in factor V (Leiden), factor II (prothrombin), and mutation in genes for methylenetetrahydrofolate reductase-MTHFR (C677T and A1298C). Results. The genotypic frequency of Leiden allele G1691A was significantly associated with a risk of unsuccessful PTA in comparison with successful PTA group and control group (OR 8.8 (1.1-70.6), p = 0.041, and OR 9.8 (1.2-79.2), p = 0.032, resp.). However, we only observed a trend for the association of the prothrombin allele G20210A and risk of PTA failure. The frequencies of alleles of MTHFR 677 or 1298 did not differ significantly among the groups. Conclusion. Our study showed higher frequency of heterozygous form of Leiden mutation in diabetic patients with unsuccessful outcome of PTA in comparison with patients with successful PTA and diabetic patients without PAD.
References provided by Crossref.org
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