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Treatment Steps, Surgery, and Hospitalization Rates During the First Year of Follow-up in Patients with Inflammatory Bowel Diseases from the 2011 ECCO-Epicom Inception Cohort
Z. Vegh, J. Burisch, N. Pedersen, I. Kaimakliotis, D. Duricova, M. Bortlik, KK. Vinding, S. Avnstrøm, J. Olsen, KR. Nielsen, KH. Katsanos, EV. Tsianos, L. Lakatos, D. Schwartz, S. Odes, R. D'Incà, M. Beltrami, G. Kiudelis, L. Kupcinskap, A....
Language English Country England, Great Britain
Document type Comparative Study, Journal Article, Multicenter Study, Observational Study, Research Support, Non-U.S. Gov't
- MeSH
- Databases, Factual MeSH
- Adult MeSH
- Phenotype MeSH
- Hospitalization statistics & numerical data MeSH
- Inflammatory Bowel Diseases diagnosis epidemiology therapy MeSH
- Immunosuppressive Agents therapeutic use MeSH
- Incidence MeSH
- Colectomy statistics & numerical data utilization MeSH
- Combined Modality Therapy MeSH
- Practice Patterns, Physicians' statistics & numerical data MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Follow-Up Studies MeSH
- Prospective Studies MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Observational Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Geographicals
- Australia MeSH
- Europe MeSH
BACKGROUND AND AIMS: The ECCO-EpiCom study investigates the differences in the incidence and therapeutic management of inflammatory bowel diseases [IBD] between Eastern and Western Europe. The aim of this study was to analyse the differences in the disease phenotype, medical therapy, surgery, and hospitalization rates in the ECCO-EpiCom 2011 inception cohort during the first year after diagnosis. METHODS: Nine Western, five Eastern European centres and one Australian centre with 258 Crohn's disease [CD], 380 ulcerative colitis [UC] and 71 IBD unclassified [IBDU] patients [female/male: 326/383; mean age at diagnosis: 40.9 years, SD: 17.3 years] participated. Patients' data were registered and entered in the web-based ECCO-EpiCom database [www.epicom-ecco.eu]. RESULTS: In CD, 36 [19%] Western Europe/Australian and 6 [9%] Eastern European patients received biological therapy [p = 0.04], but the immunosuppressive [IS] use was equal and high in these regions [Eastern Europe vs Western Europe/Australia: 53% vs 45%; p = 0.27]. Surgery was performed in 17 [24%] CD patients in Eastern Europe and 13 [7%] in Western Europe/Australia [p < 0.001, pLogRank = 0.001]. Of CD patients from Eastern Europe, 24 [34%] were hospitalized, and 39 [21%] from Western Europe/Australia, [p = 0.02, pLogRank = 0.01]. In UC, exposure to biologicals and colectomy rates were low and hospitalization rates did not differ between these regions during the 1-year follow-up period [16% vs 16%; p = 0.93]. CONCLUSIONS: During the first year after diagnosis, surgery and hospitalization rates were significantly higher in CD patients in Eastern Europe compared with Western Europe/Australia, whereas significantly more CD patients were treated with biologicals in the Western Europe/Australian centres.
1st Department of Medicine Semmelweis University Budapest Hungary
Clinic of Gastroenterology University of Medicine 'Victor Babes' Timisoara Romania
Department C Gastroenterology Section Herlev and Gentofte Hospital Hellerup Denmark
Department of Gastroenterology St Vincent's Hospital Melbourne Victoria Australia
Department of Medicine Amager Hospital Amager Denmark
Department of Medicine Csolnoky F Province Hospital Veszprem Hungary
Digestive Disease Centre Medical Section Herlev University Hospital Copenhagen Denmark
Gastro Unit Medical Section North Zealand Hospital University of Copenhagen Denmark
Gastroenterology Department Slagelse University Hospital Slagelse Denmark
Gastrounit Medical Section Hvidovre University Hospital Hvidovre Denmark
Hospital de Vale de Sousa Porto Portugal
IBD Centre ISCARE Charles University Prague Czech Republic
Institute for Digestive Research Lithuanian University of Health Sciences Kaunas Lithuania
Medical Department National Hospital of the Faroe Islands Torshavn Faroe Islands
References provided by Crossref.org
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- $a Treatment Steps, Surgery, and Hospitalization Rates During the First Year of Follow-up in Patients with Inflammatory Bowel Diseases from the 2011 ECCO-Epicom Inception Cohort / $c Z. Vegh, J. Burisch, N. Pedersen, I. Kaimakliotis, D. Duricova, M. Bortlik, KK. Vinding, S. Avnstrøm, J. Olsen, KR. Nielsen, KH. Katsanos, EV. Tsianos, L. Lakatos, D. Schwartz, S. Odes, R. D'Incà, M. Beltrami, G. Kiudelis, L. Kupcinskap, A. Jucov, S. Turcan, LF. Barros, F. Magro, D. Lazar, A. Goldis, L. de Castro, V. Hernandez, O. Niewiadomski, S. Bell, E. Langholz, P. Munkholm, PL. Lakatos, . ,
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- $a BACKGROUND AND AIMS: The ECCO-EpiCom study investigates the differences in the incidence and therapeutic management of inflammatory bowel diseases [IBD] between Eastern and Western Europe. The aim of this study was to analyse the differences in the disease phenotype, medical therapy, surgery, and hospitalization rates in the ECCO-EpiCom 2011 inception cohort during the first year after diagnosis. METHODS: Nine Western, five Eastern European centres and one Australian centre with 258 Crohn's disease [CD], 380 ulcerative colitis [UC] and 71 IBD unclassified [IBDU] patients [female/male: 326/383; mean age at diagnosis: 40.9 years, SD: 17.3 years] participated. Patients' data were registered and entered in the web-based ECCO-EpiCom database [www.epicom-ecco.eu]. RESULTS: In CD, 36 [19%] Western Europe/Australian and 6 [9%] Eastern European patients received biological therapy [p = 0.04], but the immunosuppressive [IS] use was equal and high in these regions [Eastern Europe vs Western Europe/Australia: 53% vs 45%; p = 0.27]. Surgery was performed in 17 [24%] CD patients in Eastern Europe and 13 [7%] in Western Europe/Australia [p < 0.001, pLogRank = 0.001]. Of CD patients from Eastern Europe, 24 [34%] were hospitalized, and 39 [21%] from Western Europe/Australia, [p = 0.02, pLogRank = 0.01]. In UC, exposure to biologicals and colectomy rates were low and hospitalization rates did not differ between these regions during the 1-year follow-up period [16% vs 16%; p = 0.93]. CONCLUSIONS: During the first year after diagnosis, surgery and hospitalization rates were significantly higher in CD patients in Eastern Europe compared with Western Europe/Australia, whereas significantly more CD patients were treated with biologicals in the Western Europe/Australian centres.
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