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Revelation of the IFNα, IL-10, IL-8 and IL-1β as promising biomarkers reflecting immuno-pathological mechanisms in porcine Huntington's disease model
I. Valekova, K. Jarkovska, E. Kotrcova, J. Bucci, Z. Ellederova, S. Juhas, J. Motlik, SJ. Gadher, H. Kovarova,
Journal of neuroimmunology.
2016 ;
293 (-) :
71-81.
[pub] 20160220
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc16027557
- MeSH
- biologické markery metabolismus MeSH
- centrální nervový systém cytologie patologie MeSH
- cytokiny metabolismus MeSH
- DNA vazebné proteiny metabolismus MeSH
- geneticky modifikovaná zvířata MeSH
- Huntingtonova nemoc genetika metabolismus patologie MeSH
- interferon alfa metabolismus MeSH
- interleukin-10 metabolismus MeSH
- interleukin-1beta metabolismus MeSH
- interleukin-8 metabolismus MeSH
- kultivované buňky MeSH
- lidé MeSH
- lipopolysacharidy farmakologie MeSH
- mikroglie účinky léků metabolismus MeSH
- miniaturní prasata MeSH
- modely nemocí na zvířatech MeSH
- monocyty účinky léků metabolismus MeSH
- prasata MeSH
- proteiny nervové tkáně genetika metabolismus MeSH
- regulace genové exprese genetika MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Studies on Huntington's disease (HD) demonstrated altered immune response in HD gene carriers. Using multiplexing immunoassay, we simultaneously investigated seven cytokines in secretomes of microglia and blood monocytes, cerebrospinal fluid (CSF) and serum collected from transgenic HD minipigs at pre-symptomatic disease stage. Decline in IFNα and IL-10 was observed in CSF and secretome of microglia whilst elevated IL-8 and IL-1β levels were secreted by microglia. Additionally, IL-8 was increased in serum. The proportion of mutant huntingtin in microglia may have causative impact on cytokine production. IFNα, IL-10, IL-8 and IL-1β represent promising biomarkers reflecting immuno-pathological mechanisms in porcine HD model.
Research Center PIGMOD Rumburska 89 277 21 Libechov Czech Republic
Thermo Fisher Scientific 5791 Van Allen Way Carlsbad CA 92008 USA
Thermo Fisher Scientific Life Science Solutions 7335 Executive Way Frederick MD 21704 USA
Citace poskytuje Crossref.org
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