Detail
Článek
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Rapid dissemination of colistin and carbapenem resistant Acinetobacter baumannii in Central Greece: mechanisms of resistance, molecular identification and epidemiological data

O. Oikonomou, S. Sarrou, CC. Papagiannitsis, S. Georgiadou, K. Mantzarlis, E. Zakynthinos, GN. Dalekos, E. Petinaki,

. 2015 ; 15 (-) : 559. [pub] 20151209

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc16027853

BACKGROUND: Colistin-resistant/carbapenem-resistant Acinetobacter baumannii is a significant challenge for antibiotic treatment and infection control policies. Since 2012, in Central Greece an increase of colistin/pan- resistant A. baumannii has occurred, indicating the need for further analysis. METHODS: A total of 86 colistin-resistant/carbapenem-resistant out of 1228 A. baumannii clinical isolates, consecutively collected between 2012 and 2014 in a tertiary Greek hospital of Central Greece, as well as one environmental isolate from surveillance cultures were studied. Molecular typing and mechanisms of resistance to colistin and to carbapenems were assessed, whereas, epidemiological and clinical data of the patients were reviewed. RESULTS: During the study period, the rate of colistin resistance gradually increased and reached 21.1 % in 2014. All colistin-resistant/carbapenem-resistant A. baumannii belonged to 3LST ST101 clone that corresponds to the international clonal lineage II. Carbapenem resistance was associated with the presence of bla oxa-23-like, while resistance to colistin probably correlated with G54E and R109H amino acid substitutions in PmrA and PmrC, respectively. CONCLUSIONS: Epidemiological data of the patients indicated that the first detection of colistin-resistant/carbapenem-resistant ST101 clone in the University Hospital of Larissa (UHL) was associated with a patient who previously had received colistin, while, the movement of the infected patients into the hospital probably resulted to its spread.

000      
00000naa a2200000 a 4500
001      
bmc16027853
003      
CZ-PrNML
005      
20161021101303.0
007      
ta
008      
161005s2015 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1186/s12879-015-1297-x $2 doi
024    7_
$a 10.1186/s12879-015-1297-x $2 doi
035    __
$a (PubMed)26653099
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Oikonomou, O $u Department of Microbiology, University Hospital of Larissa, Larissa, Greece.
245    10
$a Rapid dissemination of colistin and carbapenem resistant Acinetobacter baumannii in Central Greece: mechanisms of resistance, molecular identification and epidemiological data / $c O. Oikonomou, S. Sarrou, CC. Papagiannitsis, S. Georgiadou, K. Mantzarlis, E. Zakynthinos, GN. Dalekos, E. Petinaki,
520    9_
$a BACKGROUND: Colistin-resistant/carbapenem-resistant Acinetobacter baumannii is a significant challenge for antibiotic treatment and infection control policies. Since 2012, in Central Greece an increase of colistin/pan- resistant A. baumannii has occurred, indicating the need for further analysis. METHODS: A total of 86 colistin-resistant/carbapenem-resistant out of 1228 A. baumannii clinical isolates, consecutively collected between 2012 and 2014 in a tertiary Greek hospital of Central Greece, as well as one environmental isolate from surveillance cultures were studied. Molecular typing and mechanisms of resistance to colistin and to carbapenems were assessed, whereas, epidemiological and clinical data of the patients were reviewed. RESULTS: During the study period, the rate of colistin resistance gradually increased and reached 21.1 % in 2014. All colistin-resistant/carbapenem-resistant A. baumannii belonged to 3LST ST101 clone that corresponds to the international clonal lineage II. Carbapenem resistance was associated with the presence of bla oxa-23-like, while resistance to colistin probably correlated with G54E and R109H amino acid substitutions in PmrA and PmrC, respectively. CONCLUSIONS: Epidemiological data of the patients indicated that the first detection of colistin-resistant/carbapenem-resistant ST101 clone in the University Hospital of Larissa (UHL) was associated with a patient who previously had received colistin, while, the movement of the infected patients into the hospital probably resulted to its spread.
650    _2
$a infekce bakteriemi rodu Acinetobacter $x epidemiologie $x mikrobiologie $7 D000151
650    _2
$a Acinetobacter baumannii $x účinky léků $x izolace a purifikace $7 D040981
650    _2
$a senioři $7 D000368
650    _2
$a antibakteriální látky $x farmakologie $7 D000900
650    _2
$a karbapenemy $x farmakologie $7 D015780
650    _2
$a kolistin $x farmakologie $7 D003091
650    _2
$a mnohočetná bakteriální léková rezistence $x účinky léků $7 D024901
650    _2
$a pulzní gelová elektroforéza $7 D016521
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a nemocnice $7 D006761
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a mikrobiální testy citlivosti $7 D008826
650    _2
$a lidé středního věku $7 D008875
650    _2
$a molekulární typizace $7 D058889
651    _2
$a Řecko $x epidemiologie $7 D006115
655    _2
$a časopisecké články $7 D016428
700    1_
$a Sarrou, S $u Department of Microbiology, University Hospital of Larissa, Larissa, Greece.
700    1_
$a Papagiannitsis, C C $u Department of Microbiology, University Hospital of Larissa, Larissa, Greece. Faculty of Medicine and University Hospital in Plzen, Charles University in Prague, Plzen, Czech Republic.
700    1_
$a Georgiadou, S $u Department of Medicine, Medical School, University of Thessaly, Larissa, Greece.
700    1_
$a Mantzarlis, K $u Department of Critical Care, Medical School, University of Thessaly, Larissa, Greece.
700    1_
$a Zakynthinos, E $u Department of Critical Care, Medical School, University of Thessaly, Larissa, Greece.
700    1_
$a Dalekos, G N $u Department of Medicine, Medical School, University of Thessaly, Larissa, Greece.
700    1_
$a Petinaki, E $u Department of Microbiology, University Hospital of Larissa, Larissa, Greece. petinaki@med.uth.gr. Department of Microbiology, Medical School, University of Thessaly, Larissa, Greece. petinaki@med.uth.gr.
773    0_
$w MED00008185 $t BMC infectious diseases $x 1471-2334 $g Roč. 15, č. - (2015), s. 559
856    41
$u https://pubmed.ncbi.nlm.nih.gov/26653099 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20161005 $b ABA008
991    __
$a 20161021101712 $b ABA008
999    __
$a ok $b bmc $g 1166167 $s 952483
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2015 $b 15 $c - $d 559 $e 20151209 $i 1471-2334 $m BMC infectious diseases $n BMC Infect Dis $x MED00008185
LZP    __
$a Pubmed-20161005

Najít záznam

Citační ukazatele

Možnosti archivace