• Je něco špatně v tomto záznamu ?

Deconjugated urinary metanephrine, normetanephrine and 3-methoxytyramine in laboratory diagnosis of pheochromocytoma and paraganglioma

R. Bílek, T. Zelinka, P. Vlček, J. Dušková, D. Michalský, K. Novák, J. Bešťák, J. Widimský

. 2015 ; 64 (Suppl 2) : S313-S322.
. 2015 ; () : S313-S322.

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc16031126

This work discusses the clinical performance of deconjugated metanephrine (MN), normetanephrine (NMN) and 3-methoxytyramine (3MT) determined in the basal first morning urine using a chromatographic method with electrochemical detection for the clinical diagnosis of pheochromocytoma (PHEO) and paraganglioma (PGL). Urine samples were collected from 44 patients (36 with PHEO, 8 with PGL) aged 54+/-17 (20-78) years (22 females, 22 males). A sampling of biological materials was performed preoperatively and about one week, six months and one year after adrenal gland surgery. The control group consisted of 34 PHEO/PGL patients more than 4 months after adrenal gland surgery. All subjects in the control group were without a diagnosis of PHEO or PGL. Clinical sensitivity was 55 % for MN, 64 % for NMN, 80 % for combination of both MN and NMN, and only 23 % for 3TM. Clinical specificity calculated from the control group was 93 % for MN, 95 % for NMN, 95 % for the combination MN and NMN, and 97 % for 3TM. Cut-off values for deconjugated metanephrines in the basal urine were 310 (MN), 690 (NMN) and 250 microg/l (3MT). Chromatographic determination of deconjugated urinary metanephrines, which is simple without the necessity of special laboratory material, can serve for the screening of PHEO or PGL patients. Urine NMN and 3MT exerts an association to malignity, and all markers are associated with tumor mass. However, the principal laboratory diagnosis of PHEO or PGL must be based on plasma-free metanephrines and plasma chromogranin A with better performance in the laboratory diagnosis of PHEO or PGL.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc16031126
003      
CZ-PrNML
005      
20170418123707.0
007      
ta
008      
161101s2015 xr d f 000 0|ENG||
009      
AR
024    7_
$a 10.33549/physiolres.933109 $2 doi
035    __
$a (PubMed)26680494
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a ENG
044    __
$a xr
100    1_
$a Bílek, Radovan, $u Institute of Endocrinology, Prague, Czech Republic $d 1954- $7 jo20000074070
245    10
$a Deconjugated urinary metanephrine, normetanephrine and 3-methoxytyramine in laboratory diagnosis of pheochromocytoma and paraganglioma / $c R. Bílek, T. Zelinka, P. Vlček, J. Dušková, D. Michalský, K. Novák, J. Bešťák, J. Widimský
520    9_
$a This work discusses the clinical performance of deconjugated metanephrine (MN), normetanephrine (NMN) and 3-methoxytyramine (3MT) determined in the basal first morning urine using a chromatographic method with electrochemical detection for the clinical diagnosis of pheochromocytoma (PHEO) and paraganglioma (PGL). Urine samples were collected from 44 patients (36 with PHEO, 8 with PGL) aged 54+/-17 (20-78) years (22 females, 22 males). A sampling of biological materials was performed preoperatively and about one week, six months and one year after adrenal gland surgery. The control group consisted of 34 PHEO/PGL patients more than 4 months after adrenal gland surgery. All subjects in the control group were without a diagnosis of PHEO or PGL. Clinical sensitivity was 55 % for MN, 64 % for NMN, 80 % for combination of both MN and NMN, and only 23 % for 3TM. Clinical specificity calculated from the control group was 93 % for MN, 95 % for NMN, 95 % for the combination MN and NMN, and 97 % for 3TM. Cut-off values for deconjugated metanephrines in the basal urine were 310 (MN), 690 (NMN) and 250 microg/l (3MT). Chromatographic determination of deconjugated urinary metanephrines, which is simple without the necessity of special laboratory material, can serve for the screening of PHEO or PGL patients. Urine NMN and 3MT exerts an association to malignity, and all markers are associated with tumor mass. However, the principal laboratory diagnosis of PHEO or PGL must be based on plasma-free metanephrines and plasma chromogranin A with better performance in the laboratory diagnosis of PHEO or PGL.
650    _2
$a nádory nadledvin $x diagnóza $x moč $7 D000310
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a biologické markery $x moč $7 D015415
650    _2
$a vysokoúčinná kapalinová chromatografie $x metody $7 D002851
650    _2
$a klinické laboratorní techniky $x metody $7 D019411
650    _2
$a dopamin $x analogy a deriváty $x moč $7 D004298
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a metanefrin $x moč $7 D008676
650    _2
$a lidé středního věku $7 D008875
650    _2
$a normetanefrin $x moč $7 D009647
650    _2
$a paragangliom $x diagnóza $x moč $7 D010235
650    _2
$a feochromocytom $x diagnóza $x moč $7 D010673
650    _2
$a mladý dospělý $7 D055815
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Zelinka, Tomáš $7 xx0074465 $u Center for Hypertension, Third Medical Department – Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
700    1_
$a Vlček, Petr, $d 1961- $7 xx0003505 $u Department of Nuclear Medicine and Endocrinology, Faculty Hospital Motol and Second Faculty of Medicine, Charles University, Prague, Czech Republic
700    1_
$a Dušková, Jaroslava, $d 1952- $7 jo2002104714 $u Czech Republic Institute of Pathology, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic
700    1_
$a Michalský, David $7 xx0091243 $u 5First Department of Surgery – Department of Abdominal, Thoracic Surgery and Traumatology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
700    1_
$a Novák, Květoslav, $d 1966- $7 xx0063922 $u Department of Urology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
700    1_
$a Bešťák, Jiří $7 xx0196071 $u Institute of Endocrinology, Prague, Czech Republic
700    1_
$a Widimský, Jiří, $d 1956- $7 jn99240001422 $u Center for Hypertension, Third Medical Department – Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 64, Suppl 2 (2015), s. S313-S322
773    0_
$t Luboslav Stárka - doyen of the Czech endocrinology $g (2015), s. S313-S322 $w MED00191409
856    41
$u http://www.biomed.cas.cz/physiolres/ $y domovská stránka časopisu
910    __
$a ABA008 $b A 4120 $c 266 $y 4 $z 0
990    __
$a 20161101 $b ABA008
991    __
$a 20170418124015 $b ABA008
999    __
$a ok $b bmc $g 1172700 $s 955784
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2015 $b 64 $c Suppl 2 $d S313-S322 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
BMC    ##
$a 2015 $d S313-S322 $m Luboslav Stárka - doyen of the Czech endocrinology $x MED00191409
LZP    __
$b NLK118 $a Pubmed-20161101

Najít záznam

Citační ukazatele

Možnosti archivace