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Neuronal substrate and effective connectivity of abnormal movement sequencing in schizophrenia
P. Zemankova, O. Lungu, J. Huttlova, M. Kerkovsky, J. Zubor, P. Lipova, M. Bares, T. Kasparek,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- dospělí MeSH
- funkční lateralita MeSH
- lidé MeSH
- lineární modely MeSH
- magnetická rezonanční tomografie MeSH
- mapování mozku * MeSH
- mladý dospělý MeSH
- mozek MeSH
- nervové dráhy MeSH
- počítačové zpracování obrazu MeSH
- pohybové poruchy etiologie patologie MeSH
- progrese nemoci MeSH
- psychomotorický výkon fyziologie MeSH
- psychosomatické poruchy etiologie MeSH
- schizofrenie komplikace MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Movement sequencing difficulties are part of the neurological soft signs (NSS), they have high clinical value because they are not always present in schizophrenia. We investigated the neuronal correlates of movement sequencing in 24 healthy controls and 24 schizophrenia patients, with (SZP SQ+) or without (SZP SQ-) sequencing difficulties. We characterized simultaneous and lagged functional connectivity between brain regions involved in movement sequencing using psychophysiological interaction (PPI) and the Granger causality modeling (GCM), respectively. Left premotor cortex (PMC) and superior parietal lobule (SPL) were specifically activated during sequential movements in all participants. Right PMC and precuneus, ipsilateral to the hand executing the task, activated during sequential movements only in healthy controls and SZP SQ-. SZP SQ+ showed hyperactivation in contralateral PMC, as compared to the other groups. PPI analysis revealed a deficit in inhibitory connections within this fronto-parietal network in SZP SQ+ during sequential task. GCM showed a significant lagged effective connectivity from right PMC to left SPL during task and rest periods in all groups and from right PMC to right precuneus in SZP SQ+ group only. Both SZP groups had a significant lagged connectivity from right to left PMC, during sequential task. Our results indicate that aberrant fronto-parietal network connectivity with cortical inhibition deficit and abnormal reliance on previous network activity are related to movement sequencing in SZP. The overactivation of motor cortex seems to be a good compensating strategy, the hyperactivation of parietal cortex is linked to motor deficit symptoms.
Citace poskytuje Crossref.org
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- $a Holštajn Zemánková, Petra $u Behavioural and Social Neuroscience Research Group, Central European Institute of Technology - Masaryk University, Brno, Czech Republic. Electronic address: petra.zemankova@ceitec.muni.cz. $7 xx0268813
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- $a Movement sequencing difficulties are part of the neurological soft signs (NSS), they have high clinical value because they are not always present in schizophrenia. We investigated the neuronal correlates of movement sequencing in 24 healthy controls and 24 schizophrenia patients, with (SZP SQ+) or without (SZP SQ-) sequencing difficulties. We characterized simultaneous and lagged functional connectivity between brain regions involved in movement sequencing using psychophysiological interaction (PPI) and the Granger causality modeling (GCM), respectively. Left premotor cortex (PMC) and superior parietal lobule (SPL) were specifically activated during sequential movements in all participants. Right PMC and precuneus, ipsilateral to the hand executing the task, activated during sequential movements only in healthy controls and SZP SQ-. SZP SQ+ showed hyperactivation in contralateral PMC, as compared to the other groups. PPI analysis revealed a deficit in inhibitory connections within this fronto-parietal network in SZP SQ+ during sequential task. GCM showed a significant lagged effective connectivity from right PMC to left SPL during task and rest periods in all groups and from right PMC to right precuneus in SZP SQ+ group only. Both SZP groups had a significant lagged connectivity from right to left PMC, during sequential task. Our results indicate that aberrant fronto-parietal network connectivity with cortical inhibition deficit and abnormal reliance on previous network activity are related to movement sequencing in SZP. The overactivation of motor cortex seems to be a good compensating strategy, the hyperactivation of parietal cortex is linked to motor deficit symptoms.
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- $a Lungu, Ovidiu $u Department of Psychiatry, University of Montreal, Centre de recherche de l'Institut Universitaire de Gériatrie de Montreal, Montreal, Canada; Centre for Research in Aging, Donald Berman Maimonides Geriatric Centre, Montreal, Canada.
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- $a Huttlova, Jitka $u Department of Psychiatry, Faculty of Medicine of the Masaryk University and University Hospital Brno, Brno, Czech Republic.
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