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Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance
F. Pietrocola, J. Pol, E. Vacchelli, S. Rao, DP. Enot, EE. Baracco, S. Levesque, F. Castoldi, N. Jacquelot, T. Yamazaki, L. Senovilla, G. Marino, F. Aranda, S. Durand, V. Sica, A. Chery, S. Lachkar, V. Sigl, N. Bloy, A. Buque, S. Falzoni, B....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
NLK
Cell Press Free Archives
od 2002-02-01 do Před 1 rokem
Free Medical Journals
od 2002 do Před 1 rokem
- MeSH
- Atg5 genetika MeSH
- autofagie MeSH
- citráty aplikace a dávkování farmakologie MeSH
- experimentální nádory dietoterapie farmakoterapie imunologie MeSH
- kalorická restrikce metody MeSH
- lidé MeSH
- methotrexát aplikace a dávkování farmakologie MeSH
- monitorování imunologické MeSH
- mutace MeSH
- myši MeSH
- nádorové buněčné linie MeSH
- protoonkogenní proteiny p21(ras) genetika MeSH
- regulační T-lymfocyty účinky léků MeSH
- spermidin aplikace a dávkování farmakologie MeSH
- transplantace nádorů MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
Caloric restriction mimetics (CRMs) mimic the biochemical effects of nutrient deprivation by reducing lysine acetylation of cellular proteins, thus triggering autophagy. Treatment with the CRM hydroxycitrate, an inhibitor of ATP citrate lyase, induced the depletion of regulatory T cells (which dampen anticancer immunity) from autophagy-competent, but not autophagy-deficient, mutant KRAS-induced lung cancers in mice, thereby improving anticancer immunosurveillance and reducing tumor mass. Short-term fasting or treatment with several chemically unrelated autophagy-inducing CRMs, including hydroxycitrate and spermidine, improved the inhibition of tumor growth by chemotherapy in vivo. This effect was only observed for autophagy-competent tumors, depended on the presence of T lymphocytes, and was accompanied by the depletion of regulatory T cells from the tumor bed.
BioTechMed Graz Humboldtstraße 50 8010 Graz Austria
Center of Clinical Investigations in Biotherapies of Cancer 1428 94800 Villejuif France
Centre Georges François Leclerc 21000 Dijon France
Department of Morphology Surgery and Experimental Medicine University of Ferrara 44121 Ferrara Italy
Faculté de Médecine Université de Bourgogne 21078 Dijon France
Gustave Roussy Cancer Campus 94800 Villejuif France
INSERM U1015 Gustave Roussy Cancer Campus 94800 Villejuif France
INSERM U1138 75006 Paris France
INSERM U1138 Centre de Recherche des Cordeliers 75006 Paris France
INSERM U866 21078 Dijon France
Institute for Molecular Biotechnology of the Austrian Academy of Sciences 1030 Vienna Austria
Institute of Molecular Biosciences NAWI Graz University of Graz Humboldtstraße 50 8010 Graz Austria
Metabolomics and Cell Biology Platforms Gustave Roussy Cancer Campus 94800 Villejuif France
Pôle de Biologie Hôpital Européen Georges Pompidou AP HP 75015 Paris France
Sotio a c 17000 Prague Czech Republic
UMR7355 CNRS and University 45067 Orléans France
Université Paris Descartes Paris 5 Sorbonne Paris Cité 75006 Paris France
Université Paris Sud Paris Saclay Faculté de Médecine 94276 Kremlin Bicêtre France
Citace poskytuje Crossref.org
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