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Gut Microbiome of Coexisting BaAka Pygmies and Bantu Reflects Gradients of Traditional Subsistence Patterns
A. Gomez, KJ. Petrzelkova, MB. Burns, CJ. Yeoman, KR. Amato, K. Vlckova, D. Modry, A. Todd, CA. Jost Robinson, MJ. Remis, MG. Torralba, E. Morton, JD. Umaña, F. Carbonero, HR. Gaskins, KE. Nelson, BA. Wilson, RM. Stumpf, BA. White, SR. Leigh, R. Blekhman,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
NLK
Cell Press Free Archives
od 2012
Directory of Open Access Journals
od 2012
Free Medical Journals
od 2012
Freely Accessible Science Journals
od 2012-01-26
Open Access Digital Library
od 2012-01-01
Open Access Digital Library
od 2012-01-26
- MeSH
- Bacteroidetes genetika MeSH
- bakteriální geny MeSH
- bakteriální RNA genetika MeSH
- černoši MeSH
- Firmicutes genetika MeSH
- genové regulační sítě MeSH
- lidé MeSH
- molekulární typizace MeSH
- paleolitická dieta MeSH
- RNA ribozomální 16S genetika MeSH
- sekvenční analýza RNA MeSH
- střevní mikroflóra genetika MeSH
- západní dieta MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Geografické názvy
- Spojené státy americké MeSH
- Středoafrická republika MeSH
To understand how the gut microbiome is impacted by human adaptation to varying environments, we explored gut bacterial communities in the BaAka rainforest hunter-gatherers and their agriculturalist Bantu neighbors in the Central African Republic. Although the microbiome of both groups is compositionally similar, hunter-gatherers harbor increased abundance of Prevotellaceae, Treponema, and Clostridiaceae, while the Bantu gut microbiome is dominated by Firmicutes. Comparisons with US Americans reveal microbiome differences between Africans and westerners but show western-like features in the Bantu, including an increased abundance of predictive carbohydrate and xenobiotic metabolic pathways. In contrast, the hunter-gatherer gut shows increased abundance of predicted virulence, amino acid, and vitamin metabolism functions, as well as dominance of lipid and amino-acid-derived metabolites, as determined through metabolomics. Our results demonstrate gradients of traditional subsistence patterns in two neighboring African groups and highlight the adaptability of the microbiome in response to host ecology.
Department of Animal and Range Sciences Montana State University Bozeman MT 59717 USA
Department of Animal Sciences University of Illinois at Urbana Champaign Urbana IL 61801 USA
Department of Anthropology Northwestern University Evanston IL 60208 USA
Department of Anthropology Purdue University West Lafayette IN 47907 USA
Department of Anthropology University of Colorado Boulder CO 80309 USA
Department of Anthropology University of Illinois at Urbana Champaign Urbana IL 61801 USA
Department of Anthropology University of North Carolina Wilmington NC 28403 USA
Department of Ecology Evolution and Behavior University of Minnesota Twin Cities MN 55108 USA
Department of Food Science University of Arkansas Fayetteville AK 72704 USA
Department of Genetics Cell Biology and Development University of Minnesota Twin Cities MN 55108 USA
Department of Microbiology University of Illinois at Urbana Champaign Urbana IL 61801 USA
Dzanga Sangha Protected Areas World Wildlife Fund Bayanga Central African Republic
Institute for Genomic Biology University of Illinois at Urbana Champaign Urbana IL 61801 USA
Institute of Vertebrate Biology Academy of Sciences of the Czech Republic Brno 603 65 Czech Republic
Citace poskytuje Crossref.org
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- $a Gomez, Andres $u Department of Genetics, Cell Biology, and Development, University of Minnesota, Twin Cities, MN 55108, USA; Department of Ecology, Evolution, and Behavior, University of Minnesota, Twin Cities, MN 55108, USA. Electronic address: agomez@jcvi.org.
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