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L1CAM expression in endometrial carcinomas: an ENITEC collaboration study
LJ. van der Putten, NC. Visser, K. van de Vijver, M. Santacana, P. Bronsert, J. Bulten, M. Hirschfeld, E. Colas, A. Gil-Moreno, A. Garcia, G. Mancebo, F. Alameda, J. Trovik, RK. Kopperud, J. Huvila, S. Schrauwen, M. Koskas, F. Walker, V....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu srovnávací studie, časopisecké články
NLK
Free Medical Journals
od 1947 do Před 1 rokem
Freely Accessible Journals
od 1947 do Před 1 rokem
PubMed Central
od 1947 do Před 1 rokem
Europe PubMed Central
od 1947 do Před 1 rokem
ProQuest Central
od 2000-01-01 do 2017-12-31
Open Access Digital Library
od 1947-01-01
Open Access Digital Library
od 1999-01-01
Nursing & Allied Health Database (ProQuest)
od 2000-01-01 do 2017-12-31
Health & Medicine (ProQuest)
od 2000-01-01 do 2017-12-31
Public Health Database (ProQuest)
od 2000-01-01 do 2017-12-31
PubMed
27505134
DOI
10.1038/bjc.2016.235
Knihovny.cz E-zdroje
- MeSH
- dospělí MeSH
- endometroidní karcinom chemie mortalita patologie MeSH
- invazivní růst nádoru MeSH
- Kaplanův-Meierův odhad MeSH
- karcinom chemie mortalita patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- lymfatické metastázy MeSH
- molekula buněčné adheze nervové L1 analýza MeSH
- nádorové proteiny analýza MeSH
- nádory endometria chemie mortalita patologie MeSH
- prognóza MeSH
- recidiva MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- staging nádorů MeSH
- stupeň nádoru MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
BACKGROUND: Identification of aggressive endometrioid endometrial carcinomas (EECs) and non-endometrioid carcinomas (NEECs) is essential to improve outcome. L1 cell adhesion molecule (L1CAM) expression is a strong prognostic marker in stage I EECs, but less is known about L1CAM expression in advanced-stage EECs and NEECs. This study analyses L1CAM expression in a clinically representative cohort of endometrial carcinomas. METHODS: The expression of L1CAM was immunohistochemically determined in 1199 endometrial carcinomas, treated at one of the European Network for Individualized Treatment of Endometrial Cancer (ENITEC) centres. Staining was considered positive when >10% of the tumour cells expressed L1CAM. The association between L1CAM expression and several clincopathological characteristics and disease outcome was calculated. RESULTS: In all, L1CAM was expressed in 10% of the 935 stage I EECs, 18% of the 160 advanced stage EECs, and 75% of the 104 NEECs. The expression of L1CAM was associated with advanced stage, nodal involvement, high tumour grade, non-endometrioid histology, lymphovascular space invasion, and distant recurrences in all cases, and with reduced survival in the EECs, but not in the NEECs. CONCLUSIONS: The expression of L1CAM is a strong predictor of poor outcome in EECs, but not NEECs. It is strongly associated with non-endometrioid histology and distant spread, and could improve the postoperative selection of high-risk endometrial carcinomas. The value of L1CAM expression in the preoperative selection of high-risk endometrial carcinomas should be studied.
Department of Obstetrics and Gynecology Hospital del Mar Passeig Marítim 25 29 Barcelona 08003 Spain
Department of Pathology Bichat Claude Bernard Hospital 46 Rue Henri Huchard Paris 75018 France
Department of Pathology Hospital del Mar Passeig Marítim 25 29 Barcelona 08003 Spain
Department of Pathology University of Turku PO Box 7245 Laskut Turku 01051 Finland
Institute of Pathology Faculty of Medicine Masaryk University Kamenice 5 Brno 625 00 Czech Republic
Citace poskytuje Crossref.org
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