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L1CAM expression in endometrial carcinomas: an ENITEC collaboration study
LJ. van der Putten, NC. Visser, K. van de Vijver, M. Santacana, P. Bronsert, J. Bulten, M. Hirschfeld, E. Colas, A. Gil-Moreno, A. Garcia, G. Mancebo, F. Alameda, J. Trovik, RK. Kopperud, J. Huvila, S. Schrauwen, M. Koskas, F. Walker, V....
Language English Country England, Great Britain
Document type Comparative Study, Journal Article
NLK
Free Medical Journals
from 1947 to 1 year ago
Freely Accessible Journals
from 1947 to 1 year ago
PubMed Central
from 1947 to 1 year ago
Europe PubMed Central
from 1947 to 1 year ago
ProQuest Central
from 2000-01-01 to 2017-12-31
Open Access Digital Library
from 1947-01-01
Open Access Digital Library
from 1999-01-01
Nursing & Allied Health Database (ProQuest)
from 2000-01-01 to 2017-12-31
Health & Medicine (ProQuest)
from 2000-01-01 to 2017-12-31
Public Health Database (ProQuest)
from 2000-01-01 to 2017-12-31
PubMed
27505134
DOI
10.1038/bjc.2016.235
Knihovny.cz E-resources
- MeSH
- Adult MeSH
- Carcinoma, Endometrioid chemistry mortality pathology MeSH
- Neoplasm Invasiveness MeSH
- Kaplan-Meier Estimate MeSH
- Carcinoma chemistry mortality pathology MeSH
- Middle Aged MeSH
- Humans MeSH
- Lymphatic Metastasis MeSH
- Neural Cell Adhesion Molecule L1 analysis MeSH
- Neoplasm Proteins analysis MeSH
- Endometrial Neoplasms chemistry mortality pathology MeSH
- Prognosis MeSH
- Recurrence MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Neoplasm Staging MeSH
- Neoplasm Grading MeSH
- Treatment Outcome MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
BACKGROUND: Identification of aggressive endometrioid endometrial carcinomas (EECs) and non-endometrioid carcinomas (NEECs) is essential to improve outcome. L1 cell adhesion molecule (L1CAM) expression is a strong prognostic marker in stage I EECs, but less is known about L1CAM expression in advanced-stage EECs and NEECs. This study analyses L1CAM expression in a clinically representative cohort of endometrial carcinomas. METHODS: The expression of L1CAM was immunohistochemically determined in 1199 endometrial carcinomas, treated at one of the European Network for Individualized Treatment of Endometrial Cancer (ENITEC) centres. Staining was considered positive when >10% of the tumour cells expressed L1CAM. The association between L1CAM expression and several clincopathological characteristics and disease outcome was calculated. RESULTS: In all, L1CAM was expressed in 10% of the 935 stage I EECs, 18% of the 160 advanced stage EECs, and 75% of the 104 NEECs. The expression of L1CAM was associated with advanced stage, nodal involvement, high tumour grade, non-endometrioid histology, lymphovascular space invasion, and distant recurrences in all cases, and with reduced survival in the EECs, but not in the NEECs. CONCLUSIONS: The expression of L1CAM is a strong predictor of poor outcome in EECs, but not NEECs. It is strongly associated with non-endometrioid histology and distant spread, and could improve the postoperative selection of high-risk endometrial carcinomas. The value of L1CAM expression in the preoperative selection of high-risk endometrial carcinomas should be studied.
Department of Obstetrics and Gynecology Hospital del Mar Passeig Marítim 25 29 Barcelona 08003 Spain
Department of Pathology Bichat Claude Bernard Hospital 46 Rue Henri Huchard Paris 75018 France
Department of Pathology Hospital del Mar Passeig Marítim 25 29 Barcelona 08003 Spain
Department of Pathology University of Turku PO Box 7245 Laskut Turku 01051 Finland
Institute of Pathology Faculty of Medicine Masaryk University Kamenice 5 Brno 625 00 Czech Republic
References provided by Crossref.org
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