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Mapping the relationship between clinical and quality-of-life outcomes in patients with ankylosing spondylitis

T. Mlcoch, L. Sedova, J. Stolfa, M. Urbanova, D. Suchy, A. Smrzova, J. Jircikova, K. Pavelka, T. Dolezal,

. 2017 ; 17 (2) : 203-211. [pub] 20160624

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, multicentrická studie, pozorovací studie

Perzistentní odkaz   https://www.medvik.cz/link/bmc17023911

AIM: To map health-related quality of life (Qol) with clinical parameters BASFI and ASDAS-CRP measure, and other covariates. METHODS: Our prospective multicenter non-interventional observation study of ankylosing spondylitis (AS) collected data about QoL and clinical outcomes on the initial and four subsequent visits. We employed simple linear regression analysis of a cross-sectional dataset, and fixed effect, random effect and pooled linear regression of a longitudinal dataset. RESULTS: We showed that BASFI and ASDAS-CRP are very strong, robust predictors of EQ-5D utilities in all regression specifications together with sex (female), invalidity, and activity impairment. Additionally, the longitudinal regression analysis showed that a fixed effect model may be a viable alternative to the most commonly used random effect model or pooled linear regression due to the nature of our dataset. CONCLUSION: This is one of the first studies using a fixed effect model in longitudinal patient-level data, although, this method has been widely used in economics.

Citace poskytuje Crossref.org

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$a Sedova, Liliana $u b Institute of Rheumatology , Prague , Czech Republic. c Clinic of Rheumatology, 1st Faculty of Medicine , Charles University in Prague , Prague , Czech Republic.
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$a Stolfa, Jiri $u b Institute of Rheumatology , Prague , Czech Republic.
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$a Urbanova, Monika $u b Institute of Rheumatology , Prague , Czech Republic.
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$a Suchy, David $u d Department of Clinical Pharmacology, Rheumatology , University Hospital Plzen , Plzen , Czech Republic.
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$a Smrzova, Andrea $u e Third Internal Clinic , University Hospital Olomouc , Olomouc , Czech Republic.
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$a Jircikova, Jitka $u a Institute of Health Economics and Technology Assessment , Prague , Czech Republic.
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