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Altered Neural Correlate of the Self-Agency Experience in First-Episode Schizophrenia-Spectrum Patients: An fMRI Study

F. Spaniel, J. Tintera, J. Rydlo, I. Ibrahim, T. Kasparek, J. Horacek, Y. Zaytseva, M. Matejka, M. Fialova, A. Slovakova, P. Mikolas, T. Melicher, N. Görnerova, C. Höschl, T. Hajek,

. 2016 ; 42 (4) : 916-925. [pub] 20151218

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc17031879

Grantová podpora
NT14291 MZ0 CEP - Centrální evidence projektů

Digitální knihovna NLK
Plný text - Článek
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NLK Free Medical Journals od 2006 do Před 1 rokem
PubMed Central od 2006 do Před 1 rokem
Europe PubMed Central od 2006 do Před 1 rokem
Medline Complete (EBSCOhost) od 1996-01-01 do Před 1 rokem

Odkazy

PubMed 26685867
DOI 10.1093/schbul/sbv188
Knihovny.cz E-zdroje

BACKGROUND: The phenomenology of the clinical symptoms indicates that disturbance of the sense of self be a core marker of schizophrenia. AIMS: To compare neural activity related to the self/other-agency judgment in patients with first-episode schizophrenia-spectrum disorders (FES, n = 35) and healthy controls (HC, n = 35). METHOD: A functional magnetic resonance imaging (fMRI) using motor task with temporal distortion of the visual feedback was employed. A task-related functional connectivity was analyzed with the use of independent component analysis (ICA). RESULTS: (1) During self-agency experience, FES showed a deficit in cortical activation in medial frontal gyrus (BA 10) and posterior cingulate gyrus, (BA 31; P < .05, Family-Wise Error [FWE] corrected). (2) Pooled-sample task-related ICA revealed that the self/other-agency judgment was dependent upon anti-correlated default mode and central-executive networks (DMN/CEN) dynamic switching. This antagonistic mechanism was substantially impaired in FES during the task. DISCUSSION: During self-agency experience, FES demonstrate deficit in engagement of cortical midline structures along with substantial attenuation of anti-correlated DMN/CEN activity underlying normal self/other-agency discriminative processes.

Citace poskytuje Crossref.org

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