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Quorum sensing ve vztahu k virulenci mikroorganismů
[Quorum sensing in relation to microbial virulence]
M. Paldrychová, E. Kvasničková, O. Maťátková, J. Masák
Language Czech Country Czech Republic
Document type Review
- Keywords
- signální molekuly, N-acyl-homoserin lakton, inhibitory quorum sensing,
- MeSH
- Anti-Bacterial Agents MeSH
- Anti-Infective Agents MeSH
- Bacteria genetics classification metabolism pathogenicity MeSH
- Drug Resistance, Bacterial MeSH
- Biofilms MeSH
- Candida albicans pathogenicity MeSH
- Garlic MeSH
- Fungi metabolism pathogenicity MeSH
- Yeasts metabolism pathogenicity MeSH
- Plants, Medicinal chemistry classification MeSH
- Cell Communication MeSH
- Pseudomonas aeruginosa pathogenicity MeSH
- Quorum Sensing * physiology genetics drug effects MeSH
- Signal Transduction MeSH
- Vibrio cholerae pathogenicity MeSH
- Virulence genetics MeSH
- Publication type
- Review MeSH
Microorganisms do not live alone, but rather they communicate using diverse „languages“. In general, each bacterial species produces and responds to a unique autoinducer signal. Gram-negative bacteria use N-acylated homoserine lactones and gram-positive bacteria use oligopeptides as autoinducers. Function of autoinducer 2 is bacterial interspecies cell-to-cell communication. The structure and function of two main signaling molecules (farnesol and tyrosol) in the C. albicans quorum sensing (QS) system were also already described. Signaling molecules control the behavior of the whole population (especially virulence factors expression). That’s why QS systems represent a new therapeutic target, especially because of an increasing worldwide antibiotic resistance. Quorum sensing inhibitors are a promising direction in the treatment of infection caused by pathogenic micro¬organisms.
Quorum sensing in relation to microbial virulence
Literatura
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