-
Je něco špatně v tomto záznamu ?
Tests of manual dexterity and speed in Parkinson's disease: Not all measure the same
E. Růžička, R. Krupička, K. Zárubová, J. Rusz, R. Jech, Z. Szabó,
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
NT14181
MZ0
CEP - Centrální evidence projektů
- MeSH
- dospělí MeSH
- hypokineze etiologie patofyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- Parkinsonova nemoc komplikace patofyziologie MeSH
- prsty ruky MeSH
- psychomotorický výkon fyziologie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
INTRODUCTION: Timed performance tests were introduced to overcome the disadvantages of subjective evaluation of bradykinesia in Parkinson's disease (PD). We aimed to verify their discriminative properties and compare them with the motion capture analysis of finger tapping. METHODS: We included 22 PD patients (10 M, 12 F), mean age 64 (range 48-82) yrs, Hoehn & Yahr stage 2 (1-2.5) and 22 (10 M, 12 F) normal controls, mean age 66 (41-82) yrs. The key tapping subtest of the Halstead-Reitan battery, the Purdue Pegboard test, and the Bradykinesia-Akinesia Incoordination (BRAIN) test were performed according to the test manuals. The finger tapping subtest of the UPDRS-III, item 23 was recorded using a contactless 3D motion capture system Optitrack-V120. Average frequency (AvgFrq), maximum opening velocity (MaxOpV) and amplitude decrement (AmpDec) were computed and simultaneous video recordings of finger tapping were rated by two experts. RESULTS: The AmpDec and MaxOpV motion capture measures best differentiated between PD patients and controls (AUC = 0.87 and 0.81). Of the instrumental tests, only the Purdue Pegboard attained significance in differentiating PD patients from controls (AUC = 0.80). In PD patients, MaxOpV correlated with the finger tapping ratings and BRAIN test, and AvgFrq correlated with the BRAIN and Halstead-Reitan test scores. Moreover, correlations were found between the Purdue Pegboard and finger tapping ratings. CONCLUSIONS: Contactless 3D motion capture of finger tapping allowed an independent analysis of individual components of bradykinesia, demonstrating the amplitude decrement and maximum opening velocity as the most powerful discriminators between PD patients and controls.
- 000
- 00000naa a2200000 a 4500
- 001
- bmc18011215
- 003
- CZ-PrNML
- 005
- 20181015092407.0
- 007
- ta
- 008
- 180404s2016 xxk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.parkreldis.2016.05.009 $2 doi
- 035 __
- $a (PubMed)27185294
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Růžička, Evžen, $u Dept. of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Kateřinská 30, CZ-120 00, Prague, Czech Republic. Electronic address: eruzi@lf1.cuni.cz. $d 1957- $7 jo20000074065
- 245 10
- $a Tests of manual dexterity and speed in Parkinson's disease: Not all measure the same / $c E. Růžička, R. Krupička, K. Zárubová, J. Rusz, R. Jech, Z. Szabó,
- 520 9_
- $a INTRODUCTION: Timed performance tests were introduced to overcome the disadvantages of subjective evaluation of bradykinesia in Parkinson's disease (PD). We aimed to verify their discriminative properties and compare them with the motion capture analysis of finger tapping. METHODS: We included 22 PD patients (10 M, 12 F), mean age 64 (range 48-82) yrs, Hoehn & Yahr stage 2 (1-2.5) and 22 (10 M, 12 F) normal controls, mean age 66 (41-82) yrs. The key tapping subtest of the Halstead-Reitan battery, the Purdue Pegboard test, and the Bradykinesia-Akinesia Incoordination (BRAIN) test were performed according to the test manuals. The finger tapping subtest of the UPDRS-III, item 23 was recorded using a contactless 3D motion capture system Optitrack-V120. Average frequency (AvgFrq), maximum opening velocity (MaxOpV) and amplitude decrement (AmpDec) were computed and simultaneous video recordings of finger tapping were rated by two experts. RESULTS: The AmpDec and MaxOpV motion capture measures best differentiated between PD patients and controls (AUC = 0.87 and 0.81). Of the instrumental tests, only the Purdue Pegboard attained significance in differentiating PD patients from controls (AUC = 0.80). In PD patients, MaxOpV correlated with the finger tapping ratings and BRAIN test, and AvgFrq correlated with the BRAIN and Halstead-Reitan test scores. Moreover, correlations were found between the Purdue Pegboard and finger tapping ratings. CONCLUSIONS: Contactless 3D motion capture of finger tapping allowed an independent analysis of individual components of bradykinesia, demonstrating the amplitude decrement and maximum opening velocity as the most powerful discriminators between PD patients and controls.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a senioři nad 80 let $7 D000369
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a prsty ruky $7 D005385
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a hypokineze $x etiologie $x patofyziologie $7 D018476
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a Parkinsonova nemoc $x komplikace $x patofyziologie $7 D010300
- 650 _2
- $a psychomotorický výkon $x fyziologie $7 D011597
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Krupička, Radim, $u Dept. of Biomedical Informatics, Czech Technical University in Prague, Faculty of Biomedical Engineering, Sítná sq. 3105, CZ-272 01, Kladno, Czech Republic. Electronic address: radim.krupicka@gmail.com. $d 1981- $7 xx0209817
- 700 1_
- $a Zárubová, Kateřina $u Dept. of Neurology, Charles University in Prague, 2nd Faculty of Medicine and Motol University Hospital, V Úvalu 84, CZ-150 06, Prague, Czech Republic. Electronic address: katzar@centrum.cz. $7 xx0155203
- 700 1_
- $a Rusz, Jan $u Dept. of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Kateřinská 30, CZ-120 00, Prague, Czech Republic. Electronic address: rusz.mz@gmail.com.
- 700 1_
- $a Jech, Robert, $u Dept. of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Kateřinská 30, CZ-120 00, Prague, Czech Republic. Electronic address: jech@cesnet.cz. $d 1969- $7 xx0082225
- 700 1_
- $a Szabó, Zoltán $u Dept. of Biomedical Informatics, Czech Technical University in Prague, Faculty of Biomedical Engineering, Sítná sq. 3105, CZ-272 01, Kladno, Czech Republic. Electronic address: szabozol@fbmi.cvut.cz. $7 jx20080304016
- 773 0_
- $w MED00006198 $t Parkinsonism & related disorders $x 1873-5126 $g Roč. 28, č. - (2016), s. 118-123
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/27185294 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20180404 $b ABA008
- 991 __
- $a 20181015092903 $b ABA008
- 999 __
- $a ok $b bmc $g 1288700 $s 1008027
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2016 $b 28 $c - $d 118-123 $e 20160507 $i 1873-5126 $m Parkinsonism & related disorders $n Parkinsonism Relat Disord $x MED00006198
- GRA __
- $a NT14181 $p MZ0
- LZP __
- $a Pubmed-20180404