-
Je něco špatně v tomto záznamu ?
Dysnatremia as a poor prognostic indicator in patients with acute subarachnoid hemorrhage
V. Spatenkova, O. Bradac, P. de Lacy, P. Skrabalek, P. Suchomel,
Jazyk angličtina Země Itálie
Typ dokumentu časopisecké články, pozorovací studie
Odkazy
PubMed
26496416
DOI
10.23736/s0390-5616.16.03411-1
Knihovny.cz E-zdroje
- MeSH
- akutní nemoc MeSH
- dospělí MeSH
- hodnocení výsledků zdravotní péče * MeSH
- hypernatremie krev epidemiologie terapie MeSH
- hyponatremie krev epidemiologie terapie MeSH
- lidé středního věku MeSH
- lidé MeSH
- péče o pacienty v kritickém stavu metody MeSH
- prognóza MeSH
- senioři MeSH
- subarachnoidální krvácení krev epidemiologie terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
BACKGROUND: Dysnatremias are common and carry a risk of poor prognosis in acute subarachnoid hemorrhage (SAH) patients. The aim of this study was to determine the frequency and outcome of dysnatremias in 344 SAH patients treated by a targeted sodium management regimen. METHODS: We performed a 10-year observational dysnatremia study. Hyponatremia was defined as serum sodium (SNa) below 135 mmol/L, hypernatremia SNa above 150 mmol/L. RESULTS: Dysnatremia occurred in 35.8% patients; this was more frequently hyponatremia (19.8%) with a mean SNa 132.23±2.09 mmol/L, (16.0% mild, 3.2% moderate, 0.6% severe). Hypernatremia occurred less commonly in 11.9%, P<0.001 with a mean SNa 154.21±3.72 mmol/L, (6.1% mild, 2.9% moderate, 2.9% severe). In 4.8% of patients there were episodes of both dysnatremias. The incidence of hypo-osmolar hyponatremia was 6.4%, Cerebral salt wasting (CSW) 3.5%, syndrome of inappropriate secretion of antidiuretic hormone (SIADH) 0.3% and Central diabetes insipidus 1.7%. The hypernatremic patients had a higher inpatient mortality rate (P=0.001) and a worse overall outcome (P<0.001) than those hyponatremic or normotremic patients. Multivariate logistic regression showed that hypernatremia was an independent risk factor for increased inpatient mortality and poor outcome in patients with SAH. CONCLUSIONS: Our 10-year targeted sodium management regimen in acute SAH patients showed that dysnatremias were frequent, predominantly hyponatremia of which the more usual causes were CSW and not SIADH. Hypernatremia was shown to be an independent risk factor for inpatient mortality and poor outcome.
Department of Clinical Biochemistry Regional Hospital Liberec Czech Republic
Department of Neurosurgery Central Military Hospital Charles University Prague Czech Republic
Department of Neurosurgery Royal Hallamshire Hospital Sheffield UK
- 000
- 00000naa a2200000 a 4500
- 001
- bmc18011333
- 003
- CZ-PrNML
- 005
- 20180420090705.0
- 007
- ta
- 008
- 180404s2017 it f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.23736/S0390-5616.16.03411-1 $2 doi
- 035 __
- $a (PubMed)26496416
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a it
- 100 1_
- $a Spatenkova, Vera $u Neurocenter, Neurointensive Care Unit, Department of Neurosurgery, Regional Hospital, Liberec, Czech Republic - vera.spatenkova@nemlib.cz.
- 245 10
- $a Dysnatremia as a poor prognostic indicator in patients with acute subarachnoid hemorrhage / $c V. Spatenkova, O. Bradac, P. de Lacy, P. Skrabalek, P. Suchomel,
- 520 9_
- $a BACKGROUND: Dysnatremias are common and carry a risk of poor prognosis in acute subarachnoid hemorrhage (SAH) patients. The aim of this study was to determine the frequency and outcome of dysnatremias in 344 SAH patients treated by a targeted sodium management regimen. METHODS: We performed a 10-year observational dysnatremia study. Hyponatremia was defined as serum sodium (SNa) below 135 mmol/L, hypernatremia SNa above 150 mmol/L. RESULTS: Dysnatremia occurred in 35.8% patients; this was more frequently hyponatremia (19.8%) with a mean SNa 132.23±2.09 mmol/L, (16.0% mild, 3.2% moderate, 0.6% severe). Hypernatremia occurred less commonly in 11.9%, P<0.001 with a mean SNa 154.21±3.72 mmol/L, (6.1% mild, 2.9% moderate, 2.9% severe). In 4.8% of patients there were episodes of both dysnatremias. The incidence of hypo-osmolar hyponatremia was 6.4%, Cerebral salt wasting (CSW) 3.5%, syndrome of inappropriate secretion of antidiuretic hormone (SIADH) 0.3% and Central diabetes insipidus 1.7%. The hypernatremic patients had a higher inpatient mortality rate (P=0.001) and a worse overall outcome (P<0.001) than those hyponatremic or normotremic patients. Multivariate logistic regression showed that hypernatremia was an independent risk factor for increased inpatient mortality and poor outcome in patients with SAH. CONCLUSIONS: Our 10-year targeted sodium management regimen in acute SAH patients showed that dysnatremias were frequent, predominantly hyponatremia of which the more usual causes were CSW and not SIADH. Hypernatremia was shown to be an independent risk factor for inpatient mortality and poor outcome.
- 650 _2
- $a akutní nemoc $7 D000208
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a péče o pacienty v kritickém stavu $x metody $7 D003422
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a hypernatremie $x krev $x epidemiologie $x terapie $7 D006955
- 650 _2
- $a hyponatremie $x krev $x epidemiologie $x terapie $7 D007010
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 12
- $a hodnocení výsledků zdravotní péče $7 D017063
- 650 _2
- $a prognóza $7 D011379
- 650 _2
- $a subarachnoidální krvácení $x krev $x epidemiologie $x terapie $7 D013345
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a pozorovací studie $7 D064888
- 700 1_
- $a Bradac, Ondrej $u Department of Neurosurgery, Central Military Hospital, Charles University, Prague, Czech Republic.
- 700 1_
- $a de Lacy, Patricia $u Department of Neurosurgery, Royal Hallamshire Hospital, Sheffield, UK.
- 700 1_
- $a Skrabalek, Pavel $u Department of Clinical Biochemistry, Regional Hospital, Liberec, Czech Republic.
- 700 1_
- $a Suchomel, Petr $u Neurocenter, Neurointensive Care Unit, Department of Neurosurgery, Regional Hospital, Liberec, Czech Republic.
- 773 0_
- $w MED00008136 $t Journal of neurosurgical sciences $x 1827-1855 $g Roč. 61, č. 4 (2017), s. 371-379
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/26496416 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20180404 $b ABA008
- 991 __
- $a 20180420090808 $b ABA008
- 999 __
- $a ok $b bmc $g 1288818 $s 1008145
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2017 $b 61 $c 4 $d 371-379 $e 20151023 $i 1827-1855 $m Journal of neurosurgical sciences $n J Neurosurg Sci $x MED00008136
- LZP __
- $a Pubmed-20180404