-
Something wrong with this record ?
Proven Invasive Pulmonary Aspergillosis in Stem Cell Transplant Recipient Due to Aspergillus sublatus, a Cryptic Species of A. nidulans
V. Chrenkova, V. Hubka, P. Cetkovsky, M. Kouba, B. Weinbergerova, P. Lyskova, L. Hornofova, P. Hubacek,
Language English Country Netherlands
Document type Case Reports, Journal Article
NLK
ProQuest Central
from 1997-04-01 to 1 year ago
Medline Complete (EBSCOhost)
from 2011-01-01 to 1 year ago
Health & Medicine (ProQuest)
from 1997-04-01 to 1 year ago
- MeSH
- Antifungal Agents administration & dosage MeSH
- Aspergillus classification cytology genetics isolation & purification MeSH
- Leukemia, Lymphocytic, Chronic, B-Cell complications MeSH
- Cytomegalovirus Infections complications diagnosis MeSH
- DNA, Fungal chemistry genetics MeSH
- Fatal Outcome MeSH
- Phylogeny MeSH
- Invasive Pulmonary Aspergillosis diagnosis drug therapy microbiology pathology MeSH
- Calmodulin genetics MeSH
- Middle Aged MeSH
- Humans MeSH
- DNA, Ribosomal Spacer chemistry genetics MeSH
- Microbial Sensitivity Tests MeSH
- Microscopy, Electron, Scanning MeSH
- Graft vs Host Disease complications diagnosis MeSH
- Transplant Recipients MeSH
- Sequence Analysis, DNA MeSH
- Cluster Analysis MeSH
- Hematopoietic Stem Cell Transplantation adverse effects MeSH
- Tubulin genetics MeSH
- Hepatitis, Viral, Human complications diagnosis MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
Invasive fungal disease represents one of the severe complications in haematopoietic stem cell transplant recipients. We describe a case of a patient treated for relapse of chronic lymphoblastic leukaemia 6 years after HSCT. The patient was treated for invasive pulmonary aspergillosis but died 3 months later from multiple organ failures consisting of haemorrhagic necrotizing fungal pneumonia, refractory chronic hepatic graft versus host disease and cytomegalovirus hepatitis. Autopsy samples revealed histopathological evidence of fungal hyphae and an unusual Aspergillus nidulans-like species was isolated in pure culture. More precise identification was achieved by using scanning electron microscopy of ascospores and sequencing of calmodulin gene, and the isolate was subsequently re-identified as A. sublatus (section Nidulantes) and showed good in vitro susceptibility against all classes of antifungals. Commonly used ITS rDNA region and β-tubulin gene fail to discriminate A. sublatus from related pathogenic species, especially A. quadrilineatus and A. nidulans. Although this is the first case of proven IPA attributed to A. sublatus, we demonstrated that at least some previously reported infections due to A. quadrilineatus were probably caused by this cryptic species.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc18033573
- 003
- CZ-PrNML
- 005
- 20200907121339.0
- 007
- ta
- 008
- 181008s2018 ne f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1007/s11046-017-0223-8 $2 doi
- 035 __
- $a (PubMed)29128933
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ne
- 100 1_
- $a Chrenková, Vanda $u Department of Medical Microbiology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, V Uvalu 84, 15006, Prague 5, Czech Republic. vanda.chrenkova@fnmotol.cz. $7 xx0159343
- 245 10
- $a Proven Invasive Pulmonary Aspergillosis in Stem Cell Transplant Recipient Due to Aspergillus sublatus, a Cryptic Species of A. nidulans / $c V. Chrenkova, V. Hubka, P. Cetkovsky, M. Kouba, B. Weinbergerova, P. Lyskova, L. Hornofova, P. Hubacek,
- 520 9_
- $a Invasive fungal disease represents one of the severe complications in haematopoietic stem cell transplant recipients. We describe a case of a patient treated for relapse of chronic lymphoblastic leukaemia 6 years after HSCT. The patient was treated for invasive pulmonary aspergillosis but died 3 months later from multiple organ failures consisting of haemorrhagic necrotizing fungal pneumonia, refractory chronic hepatic graft versus host disease and cytomegalovirus hepatitis. Autopsy samples revealed histopathological evidence of fungal hyphae and an unusual Aspergillus nidulans-like species was isolated in pure culture. More precise identification was achieved by using scanning electron microscopy of ascospores and sequencing of calmodulin gene, and the isolate was subsequently re-identified as A. sublatus (section Nidulantes) and showed good in vitro susceptibility against all classes of antifungals. Commonly used ITS rDNA region and β-tubulin gene fail to discriminate A. sublatus from related pathogenic species, especially A. quadrilineatus and A. nidulans. Although this is the first case of proven IPA attributed to A. sublatus, we demonstrated that at least some previously reported infections due to A. quadrilineatus were probably caused by this cryptic species.
- 650 _2
- $a antifungální látky $x aplikace a dávkování $7 D000935
- 650 _2
- $a Aspergillus $x klasifikace $x cytologie $x genetika $x izolace a purifikace $7 D001230
- 650 _2
- $a kalmodulin $x genetika $7 D002147
- 650 _2
- $a shluková analýza $7 D016000
- 650 _2
- $a cytomegalovirové infekce $x komplikace $x diagnóza $7 D003586
- 650 _2
- $a DNA fungální $x chemie $x genetika $7 D004271
- 650 _2
- $a mezerníky ribozomální DNA $x chemie $x genetika $7 D021903
- 650 _2
- $a fatální výsledek $7 D017809
- 650 _2
- $a nemoc štěpu proti hostiteli $x komplikace $x diagnóza $7 D006086
- 650 _2
- $a transplantace hematopoetických kmenových buněk $x škodlivé účinky $7 D018380
- 650 _2
- $a virová hepatitida u lidí $x komplikace $x diagnóza $7 D006525
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a invazivní plicní aspergilóza $x diagnóza $x farmakoterapie $x mikrobiologie $x patologie $7 D055744
- 650 _2
- $a chronická lymfatická leukemie $x komplikace $7 D015451
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a mikrobiální testy citlivosti $7 D008826
- 650 _2
- $a mikroskopie elektronová rastrovací $7 D008855
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a fylogeneze $7 D010802
- 650 _2
- $a sekvenční analýza DNA $7 D017422
- 650 _2
- $a příjemce transplantátu $7 D066027
- 650 _2
- $a tubulin $x genetika $7 D014404
- 655 _2
- $a kazuistiky $7 D002363
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Hubka, Vít, $d 1986- $7 mzk2016904736 $u Department of Botany, Faculty of Science, Charles University, Benátská 2, 128 01, Prague 2, Czech Republic. Laboratory of Fungal Genetics and Metabolism, Institute of Microbiology Academy of Science of the Czech Republic, v.v.i, Vídeňská 1083, 142 20, Prague 4, Czech Republic.
- 700 1_
- $a Cetkovsky, Petr $u Institute of Haematology and Blood Transfusion, Prague, Czech Republic.
- 700 1_
- $a Kouba, Michal $u Institute of Haematology and Blood Transfusion, Prague, Czech Republic.
- 700 1_
- $a Weinbergerova, Barbora $u Department of Internal Medicine - Haematology and Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic.
- 700 1_
- $a Lysková, Pavlína $7 xx0234045 $u Laboratory of Medical Mycology, Department of Parasitology, Mycology and Mycobacteriology Prague, Public Health Institute in Usti nad Labem, Prague, Czech Republic.
- 700 1_
- $a Hornofova, Ludmila $u Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
- 700 1_
- $a Hubacek, Petr $u Department of Medical Microbiology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, V Uvalu 84, 15006, Prague 5, Czech Republic. Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
- 773 0_
- $w MED00003440 $t Mycopathologia $x 1573-0832 $g Roč. 183, č. 2 (2018), s. 423-429
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/29128933 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20181008 $b ABA008
- 991 __
- $a 20200907121339 $b ABA008
- 999 __
- $a ok $b bmc $g 1339507 $s 1030567
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2018 $b 183 $c 2 $d 423-429 $e 20171111 $i 1573-0832 $m Mycopathologia $n Mycopathologia $x MED00003440
- LZP __
- $a Pubmed-20181008
