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The EPTN consensus-based atlas for CT- and MR-based contouring in neuro-oncology

DB. Eekers, L. In 't Ven, E. Roelofs, A. Postma, C. Alapetite, NG. Burnet, V. Calugaru, I. Compter, IEM. Coremans, M. Høyer, M. Lambrecht, PW. Nyström, AM. Romero, F. Paulsen, A. Perpar, D. de Ruysscher, L. Renard, B. Timmermann, P. Vitek, DC....

. 2018 ; 128 (1) : 37-43. [pub] 20180313

Jazyk angličtina Země Irsko

Typ dokumentu časopisecké články, práce podpořená grantem, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc19000864

PURPOSE: To create a digital, online atlas for organs at risk (OAR) delineation in neuro-oncology based on high-quality computed tomography (CT) and magnetic resonance (MR) imaging. METHODS: CT and 3 Tesla (3T) MR images (slice thickness 1 mm with intravenous contrast agent) were obtained from the same patient and subsequently fused. In addition, a 7T MR without intravenous contrast agent was obtained from a healthy volunteer. Based on discussion between experienced radiation oncologists, the clinically relevant organs at risk (OARs) to be included in the atlas for neuro-oncology were determined, excluding typical head and neck OARs previously published. The draft atlas was delineated by a senior radiation oncologist, 2 residents in radiation oncology, and a senior neuro-radiologist incorporating relevant available literature. The proposed atlas was then critically reviewed and discussed by European radiation oncologists until consensus was reached. RESULTS: The online atlas includes one CT-scan at two different window settings and one MR scan (3T) showing the OARs in axial, coronal and sagittal view. This manuscript presents the three-dimensional descriptions of the fifteen consensus OARs for neuro-oncology. Among these is a new OAR relevant for neuro-cognition, the posterior cerebellum (illustrated on 7T MR images). CONCLUSION: In order to decrease inter- and intra-observer variability in delineating OARs relevant for neuro-oncology and thus derive consistent dosimetric data, we propose this atlas to be used in photon and particle therapy. The atlas is available online at www.cancerdata.org and will be updated whenever required.

Clinic for Particle Therapy University Hospital Essen West German Cancer Center Germany

Danish Center for Particle Therapy Aarhus Denmark

Department of Immunology Genetics and Pathology Uppsala University Sweden

Department of Radiation Oncology Eberhard Carls Universität Tübingen Germany

Department of Radiation Oncology GROW School for Oncology and Developmental Biology Maastricht University Medical Centre The Netherlands

Department of Radiation Oncology Medical Faculty and University Hospital Carl Gustav Carus Technische Universität Dresden Dresden Germany

Department of Radiation Oncology University Medical Center Groningen University of Groningen The Netherlands

Department of Radiology and Nuclear Medicine MUMC Maastricht The Netherlands

Department of Radiotherapy Oncology Leuven Kanker Instituut UZ Gasthuisberg Belgium

EBG MedAustron GmbH Wiener Neustadt Austria

Erasmus Medical Centre Rotterdam The Netherlands

German Cancer Consortium Heidelberg Germany

German Cancer Consortium partnersite Essen Essen Germany

Haaglanden Medisch Centrum Department of Radiotherapy Leidschendam The Netherlands

Holland Proton Therapy Centre Delft The Netherlands

Institut Curie Radiation Oncology Department Paris and Proton Center Orsay France

Institute Curie Centre de Protonthérapie d'Orsay Orsay France

Institute Curie Paris France

Institute of Radiooncology OncoRay Helmholtz Zentrum Dresden Rossendorf Dresden Germany

Leiden University Medical Centre Department of Radiotherapy The Netherlands

National Center for Tumor Diseases partnersite Dresden Dresden Germany

OncoRay National Center for Radiation Research in Oncology Dresden Germany

Paul Scherrer Institut med Center for Proton Therapy Switzerland

Proton Therapy Center Czech Prague Czech Republic

Proton Therapy Department South East Netherlands Maastricht The Netherlands

Service de Radiothérapie Oncologique Cliniques universitaires St Luc Brussels Belgium

The Children's Brain Tumour Research Network University of Manchester Royal Manchester Children's Hospital United Kingdom

The D Lab Decision Support for Precision Medicine GROW School for Oncology and Developmental Biology Maastricht University Medical Centre The Netherlands

The Skandion Clinic Uppsala Sweden

The University of Manchester Manchester Academic Health Science Centre The Christie NHS Foundation Trust United Kingdom

University of Cambridge Department of Oncology Addenbrooke's Hospital United Kingdom

West German Proton Therapy Center Essen Germany

Citace poskytuje Crossref.org

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