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Impact of acute and subchronic inhalation exposure to PbO nanoparticles on mice
J. Lebedová, Z. Nováková, Z. Večeřa, M. Buchtová, J. Dumková, B. Dočekal, L. Bláhová, P. Mikuška, I. Míšek, A. Hampl, K. Hilscherová,
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Administration, Inhalation MeSH
- Glutathione metabolism MeSH
- Inhalation Exposure adverse effects MeSH
- Liver drug effects MeSH
- Kidney drug effects MeSH
- Brain drug effects MeSH
- Mice MeSH
- Nanoparticles administration & dosage chemistry toxicity MeSH
- Lead administration & dosage chemistry pharmacokinetics toxicity MeSH
- Oxides administration & dosage chemistry pharmacokinetics toxicity MeSH
- Lipid Peroxidation drug effects MeSH
- Lung drug effects MeSH
- Tissue Distribution MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Lead nanoparticles (NPs) are released into air from metal processing, road transport or combustion processes. Inhalation exposure is therefore very likely to occur. However, even though the effects of bulk lead are well known, there is limited knowledge regarding impact of Pb NPs inhalation. This study focused on acute and subchronic exposures to lead oxide nanoparticles (PbO NPs). Mice were exposed to PbO NPs in whole body inhalation chambers for 4-72 h in acute experiment (4.05 × 106 PbO NPs/cm3), and for 1-11 weeks in subchronic experiment (3.83 × 105 particles/cm3 in lower and 1.93 × 106 particles/cm3 in higher exposure group). Presence of NPs was confirmed in all studied organs, including brain, which is very important considering lead neurotoxicity. Lead concentration gradually increased in all tissues depending on the exposure concentration and duration. The most burdened organs were lung and kidney, however liver and brain also showed significant increase of lead concentration during exposure. Histological analysis documented numerous morphological alterations and tissue damage, mainly in lung, but also in liver. Mild pathological changes were observed also in kidney and brain. Levels of glutathione (reduced and oxidized) were modulated mainly in lung in both, acute and subchronic exposures. Increase of lipid peroxidation was observed in kidney after acute exposure. This study characterized impacts of short to longer-term inhalation exposure, proved transport of PbO NPs to secondary organs, documented time and concentration dependent gradual increase of Pb concentration and histopathological damage in tissues.
b Institute of Analytical Chemistry of the Czech Academy of Sciences Brno Czech Republic
c Institute of Animal Physiology and Genetics of the Czech Academy of Sciences Brno Czech Republic
Department of Histology and Embryology Faculty of Medicine Masaryk University Brno Czech Republic
Faculty of Science RECETOX Masaryk University Brno Czech Republic
References provided by Crossref.org
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