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Platinum, palladium, rhodium, molybdenum and strontium in blood of urban women in nine countries
G. Rentschler, I. Rodushkin, M. Cerna, C. Chen, F. Harari, R. Harari, M. Horvat, F. Hruba, L. Kasparova, K. Koppova, A. Krskova, M. Krsnik, J. Laamech, YF. Li, L. Löfmark, T. Lundh, NG. Lundström, B. Lyoussi, D. Mazej, J. Osredkar, K. Pawlas, N....
Language English Country Germany
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Middle Aged MeSH
- Humans MeSH
- Molybdenum blood MeSH
- Environmental Monitoring * MeSH
- Palladium blood MeSH
- Platinum blood MeSH
- Rhodium blood MeSH
- Strontium blood MeSH
- Metals, Heavy blood MeSH
- Cities MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Cities MeSH
BACKGROUND: There is little reliable information on human exposure to the metals platinum (Pt), palladium (Pd) and rhodium (Rh), despite their use in enormous quantities in catalytic converters for automobile exhaust systems. OBJECTIVES: To evaluate blood concentrations of Pt (B-Pt), Pd (B-Pd) and Rh (B-Rh) in women from six European and three non-European countries, and to identify potentially influential factors. In addition, molybdenum (Mo) and strontium (Sr) were analysed. METHODS: Blood from 248 women aged 47-61 was analysed by high resolution inductively coupled plasma mass spectrometry under strict quality control. RESULTS: The medians were: B-Pt 0.8 (range <0.6-5.2), B-Pd <5 (<5-9.3), B-Rh <0.4 (<0.4-3.6)ng/L and B-Mo 2.0 (0.2-16) and B-Sr 16.6 (3.5-49) μg/L. Two women with highly elevated B-Pt (242 and 60ng/L), previously cancer treated with cis-platinum, were not included in the data analysis. All elements varied geographically (2-3 times) (B-Pd P=0.05; all other elements P<0.001); variations within each area were generally 5-10 times. Traffic was not associated with increased concentrations. CONCLUSIONS: General population blood concentrations of Pt, Pd and Rh are within or below the single digit ng/L range, much lower than in most previous reports. This is probably due to improved analytical performance, allowing for more reliable information at ultra-trace levels. In general, Mo and Sr agreed with previously reported concentrations. All elements showed geographical and inter-individual variations, but no convincing relationships with self-reported traffic intensity were found. Pt from the antineoplastic drug cis-platinum is retained in the body for years.
ALS Scandinavia AB Luleå Sweden
Department of Biobank Research Umeå University Umeå Sweden
Department of Environmental Sciences Institut Jožef Stefan Ljubljana Slovenia
Department of General Hygiene 3rd Faculty of Medicine Charles University Prague Czech Republic
Division of Occupational and Environmental Medicine Lund University Lund Sweden
Institute for Clinical Chemistry and Biochemistry Ljubljana Slovenia
Institute for the Development of Production and Work Environment Quito Ecuador
Institute of High Energy Physics Chinese Academy of Sciences Beijing China
Institute of Occupational Medicine and Environmental Health Sosnowiec Poland
National Institute of Public Health Prague Czech Republic
Regional Authority of Public Health Banska Bystrica Slovakia
Slovak Medical University Bratislava Faculty of Health Care Banska Bystrica Slovakia
References provided by Crossref.org
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