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Impact of body mass index on the outcome of catheter ablation of atrial fibrillation
BM. Glover, KL. Hong, N. Dagres, E. Arbelo, C. Laroche, S. Riahi, M. Bertini, EN. Mikhaylov, J. Galvin, M. Kiliszek, E. Pokushalov, J. Kautzner, N. Calvo, C. Blomström-Lundqvist, J. Brugada, ESC-EHRA Atrial Fibrillation Ablation Long-Term...
Language English Country England, Great Britain
Document type Journal Article, Multicenter Study, Observational Study, Research Support, Non-U.S. Gov't
NLK
ProQuest Central
from 1996-01-01 to 3 months ago
Health & Medicine (ProQuest)
from 1996-01-01 to 3 months ago
- MeSH
- Risk Reduction Behavior MeSH
- Radiation Dosage MeSH
- Atrial Fibrillation * epidemiology therapy MeSH
- Fluoroscopy * methods statistics & numerical data MeSH
- Risk Assessment MeSH
- Body Mass Index MeSH
- Catheter Ablation * adverse effects methods MeSH
- Comorbidity MeSH
- Correlation of Data MeSH
- Middle Aged MeSH
- Humans MeSH
- Overweight * diagnosis epidemiology MeSH
- Follow-Up Studies MeSH
- Obesity * diagnosis epidemiology psychology MeSH
- Recurrence MeSH
- Registries statistics & numerical data MeSH
- Risk Factors MeSH
- Aged MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Observational Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Europe MeSH
OBJECTIVES: The association between obesity and atrial fibrillation (AF) is well-established. We aimed to evaluate the impact of index body mass index (BMI) on AF recurrence at 12 months following catheter ablation using propensity-weighted analysis. In addition, periprocedural complications and fluoroscopy details were examined to assess overall safety in relationship to increasing BMI ranges. METHODS: Baseline, periprocedural and follow-up data were collected on consecutive patients scheduled for AF ablation. There were no specific exclusion criteria. Patients were categorised according to baseline BMI in order to assess the outcomes for each category. RESULTS: Among 3333 patients, 728 (21.8%) were classified as normal (BMI <25.0 kg/m2), 1537 (46.1%) as overweight (BMI 25.5-29.0 kg/m2) and 1068 (32.0%) as obese (BMI ≥30.0 kg/m2). Procedural duration and radiation dose were higher for overweight and obese patients compared with those with a normal BMI (p=0.002 and p<0.001, respectively). An index BMI ≥30 kg/m2 led to a 1.2-fold increased likelihood of experiencing recurrent AF at 12-months follow-up as compared with overweight patients (HR 1.223; 95% CI 1.047 to 1.429; p=0.011), while no significant correlation was found between overweight and normal BMI groups (HR 0.954; 95% CI 0.798 to 1.140; p=0.605) and obese versus normal BMI (HR 1.16; 95% CI 0.965 to 1.412; p=0.112). CONCLUSIONS: Patients with a baseline BMI ≥30 kg/m2 have a higher recurrence rate of AF following catheter ablation and therefore lifestyle modification to target obesity preprocedure should be considered in these patients.
Cardiology Department Clinica Universidad de Navarra Pamplona Spain
Cardiology Department Mater Misericordiae University Hospital Dublin Ireland
Department of Cardiology and Internal Diseases Military Institute of Medicine Warsaw Poland
Department of Cardiology Queen's University Kingston Ontario Canada
Department of Cardiology S Anna Hospital University of Ferrara Ferrara Italy
Department of Electrophysiology University Leipzig Heart Center Leipzig Germany
Department of Medical Science and Cardiology Uppsala University Uppsala Sweden
EURObservational Research Programme European Society of Cardiology Sophia Antipolis France
Institute for Clinical and Experimental Medicine Prague Czech Republic
References provided by Crossref.org
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- $a OBJECTIVES: The association between obesity and atrial fibrillation (AF) is well-established. We aimed to evaluate the impact of index body mass index (BMI) on AF recurrence at 12 months following catheter ablation using propensity-weighted analysis. In addition, periprocedural complications and fluoroscopy details were examined to assess overall safety in relationship to increasing BMI ranges. METHODS: Baseline, periprocedural and follow-up data were collected on consecutive patients scheduled for AF ablation. There were no specific exclusion criteria. Patients were categorised according to baseline BMI in order to assess the outcomes for each category. RESULTS: Among 3333 patients, 728 (21.8%) were classified as normal (BMI <25.0 kg/m2), 1537 (46.1%) as overweight (BMI 25.5-29.0 kg/m2) and 1068 (32.0%) as obese (BMI ≥30.0 kg/m2). Procedural duration and radiation dose were higher for overweight and obese patients compared with those with a normal BMI (p=0.002 and p<0.001, respectively). An index BMI ≥30 kg/m2 led to a 1.2-fold increased likelihood of experiencing recurrent AF at 12-months follow-up as compared with overweight patients (HR 1.223; 95% CI 1.047 to 1.429; p=0.011), while no significant correlation was found between overweight and normal BMI groups (HR 0.954; 95% CI 0.798 to 1.140; p=0.605) and obese versus normal BMI (HR 1.16; 95% CI 0.965 to 1.412; p=0.112). CONCLUSIONS: Patients with a baseline BMI ≥30 kg/m2 have a higher recurrence rate of AF following catheter ablation and therefore lifestyle modification to target obesity preprocedure should be considered in these patients.
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