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Porcine cytochrome 2A19 and 2E1
V. Burkina, MK. Rasmussen, Y. Oliinychenko, G. Zamaratskaia,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, přehledy
Grantová podpora
CZ.1.05/2.1.00/01.0024
Ministry of Education, Youth and Sports of the Czech Republic-projects CENAKVA
CZ.1.05/2.1.00/19.0380
CENAKVA Center Development
LO1205
CENAKVA II
CZ.02.2.69/0.0/0.0/16_027/0008364
Development of USB-International mobility
Lundbeck Foundation
PubMed
30171805
DOI
10.1111/bcpt.13121
Knihovny.cz E-zdroje
- MeSH
- biotransformace MeSH
- cytochrom P-450 CYP2E1 genetika metabolismus MeSH
- cytochrom P450 CYP2A6 genetika metabolismus MeSH
- krmivo pro zvířata * MeSH
- lidé MeSH
- pohlavní steroidní hormony metabolismus MeSH
- prasata metabolismus MeSH
- sekvenční homologie MeSH
- skatol metabolismus MeSH
- xenobiotika metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Cytochrome P450 (CYP) is a major group of enzymes, which conduct Phase I metabolism. Among commonly used animal models, the pig has been suggested as the most suitable model for investigating drug metabolism in human beings. Moreover, porcine CYP2A19 and CYP2E1 are responsible for the biotransformation of both endogenous and exogenous compounds such as 3-methylindole (skatole), sex hormones and food compounds. However, little is known about the regulation of porcine CYP2A19 and CYP2E1. In this MiniReview, we summarise the current knowledge about the regulation of porcine CYP2A19 and CYP2E1 by environmental, biological and dietary factors. Finally, we reflect on the need for further research, to clarify the interaction between active feed components and the porcine CYP system.
Department of Food Science Aarhus University Foulum Denmark
Pig Breeding Institute of Ukrainian Academy Agrarian Sciences Poltava Ukraine
Citace poskytuje Crossref.org
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