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Orosensory detection of bitter in fat-taster healthy and obese participants: Genetic polymorphism of CD36 and TAS2R38
I. Karmous, J. Plesník, AS. Khan, O. Šerý, A. Abid, A. Mankai, A. Aouidet, NA. Khan,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- antigeny CD36 genetika MeSH
- chuť genetika MeSH
- dospělí MeSH
- jednonukleotidový polymorfismus genetika MeSH
- lidé MeSH
- obezita * epidemiologie genetika MeSH
- propylthiouracil MeSH
- receptory spřažené s G-proteiny genetika MeSH
- studie případů a kontrol MeSH
- tělesná hmotnost genetika MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
BACKGROUND & AIMS: We assessed orosensory detection of a long-chain fatty acid, linoleic acid (LA), and a bitter taste marker, 6-n-propylthiouracil (PROP), and correlated lipid-taster subjects with PROP detection and polymorphism in genes encoding bitter and lipid taste receptors, respectively, TAS2R38 and CD36, in normal weight and obese subjects. DESIGN: The normal weight (n = 52, age = 35.3 ± 4.10 years, BMI = 23.22 ± 1.44 kg/m2) and obese (n = 52, age = 35.0 ± 5.43 years, BMI = 34.29 ± 5.31 kg/m2) participants were recruited to determine fat and bitter detection thresholds. The genomic DNA was used to determine single nucleotide polymorphism (SNP) of CD36 (rs1761667) and TAS2R38 (rs1726866 and rs10246939). RESULTS: The study included the participants who could detect LA, i.e., lipid-tasters. There was a positive correlation between BMI and detection thresholds for fat and bitter taste in normal weight and obese subjects. Obese participants showed a positive correlation between LA and PROP detection thresholds. PROP detection thresholds were higher for CD36 SNP (rs1761667) and TAS2R38 SNPs (rs1726866 and rs10246939) in obese participants compared to normal weight subjects. LA detection thresholds were not high for CD36 SNP (rs1761667) or TAS2R38 SNP (rs1726866 and rs10246939) in obese participants. CONCLUSIONS: Orosensory detection thresholds for fat and bitter taste are associated with BMI, and CD36 and TAS2R38 genotypes are not always associated with taste phenotypes.
Faculté des Sciences de Bizerte Jarzouna Bizerte Tunisia
Higher School of Health and Technical Sciences Tunis El Manar University Tunisia
Institute of Animal Physiology and Genetics Academy of Science Brno Czech Republic
Citace poskytuje Crossref.org
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- $a Karmous, Inchirah $u Higher School of Health and Technical Sciences, Tunis El Manar University, Tunisia; Physiologie de la Nutrition & Toxicologie, INSERM UMR 1231, Université de Bourgogne-Franche Comté (UBFC), Dijon, France; Faculté des Sciences de Bizerte, Jarzouna-Bizerte, Tunisia.
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- $a Orosensory detection of bitter in fat-taster healthy and obese participants: Genetic polymorphism of CD36 and TAS2R38 / $c I. Karmous, J. Plesník, AS. Khan, O. Šerý, A. Abid, A. Mankai, A. Aouidet, NA. Khan,
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- $a BACKGROUND & AIMS: We assessed orosensory detection of a long-chain fatty acid, linoleic acid (LA), and a bitter taste marker, 6-n-propylthiouracil (PROP), and correlated lipid-taster subjects with PROP detection and polymorphism in genes encoding bitter and lipid taste receptors, respectively, TAS2R38 and CD36, in normal weight and obese subjects. DESIGN: The normal weight (n = 52, age = 35.3 ± 4.10 years, BMI = 23.22 ± 1.44 kg/m2) and obese (n = 52, age = 35.0 ± 5.43 years, BMI = 34.29 ± 5.31 kg/m2) participants were recruited to determine fat and bitter detection thresholds. The genomic DNA was used to determine single nucleotide polymorphism (SNP) of CD36 (rs1761667) and TAS2R38 (rs1726866 and rs10246939). RESULTS: The study included the participants who could detect LA, i.e., lipid-tasters. There was a positive correlation between BMI and detection thresholds for fat and bitter taste in normal weight and obese subjects. Obese participants showed a positive correlation between LA and PROP detection thresholds. PROP detection thresholds were higher for CD36 SNP (rs1761667) and TAS2R38 SNPs (rs1726866 and rs10246939) in obese participants compared to normal weight subjects. LA detection thresholds were not high for CD36 SNP (rs1761667) or TAS2R38 SNP (rs1726866 and rs10246939) in obese participants. CONCLUSIONS: Orosensory detection thresholds for fat and bitter taste are associated with BMI, and CD36 and TAS2R38 genotypes are not always associated with taste phenotypes.
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- $a Khan, Amira Sayed $u Physiologie de la Nutrition & Toxicologie, INSERM UMR 1231, Université de Bourgogne-Franche Comté (UBFC), Dijon, France; Département de Biochimie, Biologie Cellulaire et Moléculaire, Université des Frères Mentouri, Constantine 1, Alegria.
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- $a Šerý, Omar $u Laboratory of Neurobiology and Molecular Psychiatry, Laboratory of Molecular Physiology, Department of Biochemistry, Faculty of Science, Masaryk University, Brno, Czech Republic; Institute of Animal Physiology and Genetics, Academy of Science, Brno, Czech Republic.
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