Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Accuracy of Colon Capsule Endoscopy for Colorectal Neoplasia Detection in Individuals Referred for a Screening Colonoscopy

M. Voska, M. Zavoral, T. Grega, O. Majek, J. Martinek, I. Tacheci, M. Benes, G. Vojtechova, P. Drastich, J. Bures, J. Spicak, B. Buckova, O. Ngo, S. Suchanek,

. 2019 ; 2019 (-) : 5975438. [pub] 20190903

Jazyk angličtina Země Egypt

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc19044268

Grantová podpora
NV16-29614A MZ0 CEP - Centrální evidence projektů

Backround: Capsule colonoscopy might present an alternative to colonoscopy for colorectal neoplasia screening. Aim: To assess the accuracy of second-generation capsule colonoscopy (CCE2) for colorectal neoplasia detection compared with conventional colonoscopy (CC). Methods: From 2011-2015, we performed a multicenter, prospective, cross-over study evaluating the use of CCE2 as a possible colorectal cancer (CRC) screening test based on the assessment of the method's characteristics (accuracy) and safety and patient acceptance of the routine. Enrolled participants fulfilled the CRC screening population criteria if they were asymptomatic, were older than 50, and had no personal or familial history of colorectal neoplasia. The primary outcome was accuracy for the detection of polyps ≥ 6 mm. Secondary outcomes were accuracy for all polyps, polyps ≥ 10 mm, adenomas ≥ 10 mm, and cancers, the quality of bowel cleansing, safety, and CCE2 acceptability by the screening population. Results: A total of 236 individuals were examined; 11 patients (5%) were excluded. Therefore, 225 subjects (95%) were considered in the intention-to-screen (ITS) group. A total of 201 patients (89%) completed both examinations successfully (per protocol group). In the ITS group, polyps were diagnosed during CC in 114 subjects (51%); polyps ≥ 6 mm, polyps ≥ 10 mm, and adenomas ≥ 10 mm were diagnosed in 34 (15%), 16 (7%), and 11 (5%) patients, respectively. The sensitivity of CCE2 for polyps ≥ 6 mm, polyps ≥ 10 mm, and adenomas ≥ 10 mm was 79% (95% confidence interval (CI): 62-91%), 88% (95% CI: 62-98%), and 100% (95% CI: 72-100%), respectively. Conclusion: Second-generation capsule colonoscopy is a safe, noninvasive, and sensitive method for colorectal neoplasia detection although CC remains the preferred method for considerable proportion of subjects. CCE2 may therefore be accepted as the primary screening test for colorectal cancer screening.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19044268
003      
CZ-PrNML
005      
20200109095637.0
007      
ta
008      
200107s2019 ua f 000 0|eng||
009      
AR
024    7_
$a 10.1155/2019/5975438 $2 doi
035    __
$a (PubMed)31565052
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ua
100    1_
$a Voska, Michal $u Department of Medicine, First Faculty of Medicine, Charles University, Military University Hospital, Prague, CZ 169 02, Czech Republic.
245    10
$a Accuracy of Colon Capsule Endoscopy for Colorectal Neoplasia Detection in Individuals Referred for a Screening Colonoscopy / $c M. Voska, M. Zavoral, T. Grega, O. Majek, J. Martinek, I. Tacheci, M. Benes, G. Vojtechova, P. Drastich, J. Bures, J. Spicak, B. Buckova, O. Ngo, S. Suchanek,
520    9_
$a Backround: Capsule colonoscopy might present an alternative to colonoscopy for colorectal neoplasia screening. Aim: To assess the accuracy of second-generation capsule colonoscopy (CCE2) for colorectal neoplasia detection compared with conventional colonoscopy (CC). Methods: From 2011-2015, we performed a multicenter, prospective, cross-over study evaluating the use of CCE2 as a possible colorectal cancer (CRC) screening test based on the assessment of the method's characteristics (accuracy) and safety and patient acceptance of the routine. Enrolled participants fulfilled the CRC screening population criteria if they were asymptomatic, were older than 50, and had no personal or familial history of colorectal neoplasia. The primary outcome was accuracy for the detection of polyps ≥ 6 mm. Secondary outcomes were accuracy for all polyps, polyps ≥ 10 mm, adenomas ≥ 10 mm, and cancers, the quality of bowel cleansing, safety, and CCE2 acceptability by the screening population. Results: A total of 236 individuals were examined; 11 patients (5%) were excluded. Therefore, 225 subjects (95%) were considered in the intention-to-screen (ITS) group. A total of 201 patients (89%) completed both examinations successfully (per protocol group). In the ITS group, polyps were diagnosed during CC in 114 subjects (51%); polyps ≥ 6 mm, polyps ≥ 10 mm, and adenomas ≥ 10 mm were diagnosed in 34 (15%), 16 (7%), and 11 (5%) patients, respectively. The sensitivity of CCE2 for polyps ≥ 6 mm, polyps ≥ 10 mm, and adenomas ≥ 10 mm was 79% (95% confidence interval (CI): 62-91%), 88% (95% CI: 62-98%), and 100% (95% CI: 72-100%), respectively. Conclusion: Second-generation capsule colonoscopy is a safe, noninvasive, and sensitive method for colorectal neoplasia detection although CC remains the preferred method for considerable proportion of subjects. CCE2 may therefore be accepted as the primary screening test for colorectal cancer screening.
655    _2
$a časopisecké články $7 D016428
700    1_
$a Zavoral, Miroslav $u Department of Medicine, First Faculty of Medicine, Charles University, Military University Hospital, Prague, CZ 169 02, Czech Republic.
700    1_
$a Grega, Tomas $u Department of Medicine, First Faculty of Medicine, Charles University, Military University Hospital, Prague, CZ 169 02, Czech Republic.
700    1_
$a Majek, Ondrej $u Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, CZ 625 00, Czech Republic.
700    1_
$a Martinek, Jan $u Department of Medicine, First Faculty of Medicine, Charles University, Military University Hospital, Prague, CZ 169 02, Czech Republic. Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, CZ 140 21, Czech Republic. Charles University in Prague, Institute of Physiology, Czech Republic. University of Ostrava, Medical Faculty, Czech Republic.
700    1_
$a Tacheci, Ilja $u 2nd Department of Internal Medicine-Gastroenterology, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, CZ 500 05, Czech Republic.
700    1_
$a Benes, Marek $u Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, CZ 140 21, Czech Republic. GEP Clinic, Prague, CZ 130 00, Czech Republic.
700    1_
$a Vojtechova, Gabriela $u Department of Medicine, First Faculty of Medicine, Charles University, Military University Hospital, Prague, CZ 169 02, Czech Republic.
700    1_
$a Drastich, Pavel $u Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, CZ 140 21, Czech Republic. GEP Clinic, Prague, CZ 130 00, Czech Republic.
700    1_
$a Bures, Jan $u 2nd Department of Internal Medicine-Gastroenterology, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, CZ 500 05, Czech Republic.
700    1_
$a Spicak, Julius $u Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, CZ 140 21, Czech Republic.
700    1_
$a Buckova, Barbora $u Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, CZ 625 00, Czech Republic.
700    1_
$a Ngo, Ondrej $u Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, CZ 625 00, Czech Republic.
700    1_
$a Suchanek, Stepan $u Department of Medicine, First Faculty of Medicine, Charles University, Military University Hospital, Prague, CZ 169 02, Czech Republic.
773    0_
$w MED00163225 $t Gastroenterology research and practice $x 1687-6121 $g Roč. 2019, č. - (2019), s. 5975438
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31565052 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20200107 $b ABA008
991    __
$a 20200109100006 $b ABA008
999    __
$a ind $b bmc $g 1480857 $s 1082938
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 2019 $c - $d 5975438 $e 20190903 $i 1687-6121 $m Gastroenterology Research and Practice $n Gastroenterol Res Pract $x MED00163225
GRA    __
$a NV16-29614A $p MZ0
LZP    __
$a Pubmed-20200107

Najít záznam

Citační ukazatele

Možnosti archivace