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Impact of drugs on venous thromboembolism risk in surgical patients
APM. Kovačič, M. Caprnda, A. Mrhar, P. Kubatka, I. Locatelli, B. Zolakova, L. Gaspar, R. Prosecky, P. Kruzliak, R. Staffa, L. Rodrigo, J. Radonak, D. Petrovič,
Language English Country Germany
Document type Journal Article, Review
Grant support
17-29701A
Ministerstvo Zdravotnictv? Cesk? Republiky
NV15-33437A
MZ0
CEP Register
Digital library NLK
Full text - Article
NLK
ProQuest Central
from 1997-01-01 to 1 year ago
CINAHL Plus with Full Text (EBSCOhost)
from 2008-01-01 to 1 year ago
Medline Complete (EBSCOhost)
from 2000-01-01 to 1 year ago
Nursing & Allied Health Database (ProQuest)
from 1997-01-01 to 1 year ago
Health & Medicine (ProQuest)
from 1997-01-01 to 1 year ago
- MeSH
- Analgesics therapeutic use MeSH
- Antidepressive Agents therapeutic use MeSH
- Antipsychotic Agents therapeutic use MeSH
- Diuretics therapeutic use MeSH
- Hormone Replacement Therapy MeSH
- Hypnotics and Sedatives therapeutic use MeSH
- Contraceptives, Oral, Hormonal therapeutic use MeSH
- Humans MeSH
- Perioperative Care * MeSH
- Risk Factors MeSH
- Venous Thromboembolism chemically induced MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
PURPOSE: This review focuses on the most common drugs administered to surgical patients during the perioperative period that affect the risk of venous thromboembolism (VTE). RESULTS: Among analgesics, the risk of VTE is increased in patients treated with diclofenac, ibuprofen, and rofecoxib, but not naproxen, while metamizole can confer a protective effect. The relationship between sedatives and VTE has not been sufficiently studied. Tricyclic antidepressants, low-potency serotonin reuptake inhibitors, and antipsychotics have been associated with increased risk of VTE. The use of diuretics in the perioperative period is poorly researched; however, hyponatremia is considered a risk factor. Other factors that may influence the risk of VTE include bridging anticoagulation, allogeneic transfusion, and hemostatic management before surgery. Pharmacotherapy for HIV or cancer may also increase VTE risk. CONCLUSION: Increased monitoring for VTE is therefore advisable in surgical patients and those receiving antipsychotics, antidepressants, diuretics, or analgesics.
Department of Internal Medicine Brothers of Mercy Hospital Brno Polni 3 63900 Brno Czech Republic
Faculty of Medicine University of Ljubljana Vrazov trg 2 SI 1104 Ljubljana Slovenia
Faculty of Medicine University of Oviedo Central University Hospital of Asturias Oviedo Spain
References provided by Crossref.org
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- $a Kovačič, Alenka Premuš Marušič $u Murska Sobota General Hospital, Murska Sobota, Slovenia. Department of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
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- $a PURPOSE: This review focuses on the most common drugs administered to surgical patients during the perioperative period that affect the risk of venous thromboembolism (VTE). RESULTS: Among analgesics, the risk of VTE is increased in patients treated with diclofenac, ibuprofen, and rofecoxib, but not naproxen, while metamizole can confer a protective effect. The relationship between sedatives and VTE has not been sufficiently studied. Tricyclic antidepressants, low-potency serotonin reuptake inhibitors, and antipsychotics have been associated with increased risk of VTE. The use of diuretics in the perioperative period is poorly researched; however, hyponatremia is considered a risk factor. Other factors that may influence the risk of VTE include bridging anticoagulation, allogeneic transfusion, and hemostatic management before surgery. Pharmacotherapy for HIV or cancer may also increase VTE risk. CONCLUSION: Increased monitoring for VTE is therefore advisable in surgical patients and those receiving antipsychotics, antidepressants, diuretics, or analgesics.
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- $a Caprnda, Martin $u 1st Department of Internal Medicine, Faculty of Medicine, University Hospital and Comenius University in Bratislava, Mickiewiczova 2247/13, 811 07, Bratislava, Slovakia.
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- $a Kubatka, Peter $u Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Malá Hora 4, 036 01, Martin, Slovakia. peter.kubatka@jfmed.uniba.sk. Department of Experimental Carcinogenesis, Division of Oncology, Biomedical Center Martin, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia. peter.kubatka@jfmed.uniba.sk.
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