Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Mature dendritic cells correlate with favorable immune infiltrate and improved prognosis in ovarian carcinoma patients

I. Truxova, L. Kasikova, M. Hensler, P. Skapa, J. Laco, L. Pecen, L. Belicova, I. Praznovec, MJ. Halaska, T. Brtnicky, E. Salkova, L. Rob, R. Kodet, J. Goc, C. Sautes-Fridman, WH. Fridman, A. Ryska, L. Galluzzi, R. Spisek, J. Fucikova,

. 2018 ; 6 (1) : 139. [pub] 20181204

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc19045097

A high density of tumor-infiltrating CD8+ T cells and CD20+ B cells correlates with prolonged survival in patients with a wide variety of human cancers, including high-grade serous ovarian carcinoma (HGSC). However, the potential impact of mature dendritic cells (DCs) in shaping the immune contexture of HGSC, their role in the establishment of T cell-dependent antitumor immunity, and their potential prognostic value for HGSC patients remain unclear. We harnessed immunohistochemical tests and biomolecular analyses to demonstrate that a high density of tumor-infiltrating DC-LAMP+ DCs is robustly associated with an immune contexture characterized by TH1 polarization and cytotoxic activity. We showed that both mature DCs and CD20+ B cells play a critical role in the generation of a clinically-favorable cytotoxic immune response in HGSC microenvironment. In line with this notion, robust tumor infiltration by both DC-LAMP+ DCs and CD20+ B cells was associated with most favorable overall survival in two independent cohorts of chemotherapy-naïve HGSC patients. Our findings suggest that the presence of mature, DC-LAMP+ DCs in the tumor microenvironment may represent a novel, powerful prognostic biomarker for HGSC patients that reflects the activation of clinically-relevant anticancer immunity.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19045097
003      
CZ-PrNML
005      
20200116141806.0
007      
ta
008      
200109s2018 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1186/s40425-018-0446-3 $2 doi
035    __
$a (PubMed)30526667
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Truxova, Iva $u Department of Immunology, Charles University, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic. Sotio, Prague, Czech Republic.
245    10
$a Mature dendritic cells correlate with favorable immune infiltrate and improved prognosis in ovarian carcinoma patients / $c I. Truxova, L. Kasikova, M. Hensler, P. Skapa, J. Laco, L. Pecen, L. Belicova, I. Praznovec, MJ. Halaska, T. Brtnicky, E. Salkova, L. Rob, R. Kodet, J. Goc, C. Sautes-Fridman, WH. Fridman, A. Ryska, L. Galluzzi, R. Spisek, J. Fucikova,
520    9_
$a A high density of tumor-infiltrating CD8+ T cells and CD20+ B cells correlates with prolonged survival in patients with a wide variety of human cancers, including high-grade serous ovarian carcinoma (HGSC). However, the potential impact of mature dendritic cells (DCs) in shaping the immune contexture of HGSC, their role in the establishment of T cell-dependent antitumor immunity, and their potential prognostic value for HGSC patients remain unclear. We harnessed immunohistochemical tests and biomolecular analyses to demonstrate that a high density of tumor-infiltrating DC-LAMP+ DCs is robustly associated with an immune contexture characterized by TH1 polarization and cytotoxic activity. We showed that both mature DCs and CD20+ B cells play a critical role in the generation of a clinically-favorable cytotoxic immune response in HGSC microenvironment. In line with this notion, robust tumor infiltration by both DC-LAMP+ DCs and CD20+ B cells was associated with most favorable overall survival in two independent cohorts of chemotherapy-naïve HGSC patients. Our findings suggest that the presence of mature, DC-LAMP+ DCs in the tumor microenvironment may represent a novel, powerful prognostic biomarker for HGSC patients that reflects the activation of clinically-relevant anticancer immunity.
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a senioři nad 80 let $7 D000369
650    _2
$a biologické markery $7 D015415
650    _2
$a karcinom $x imunologie $x mortalita $x patologie $7 D002277
650    _2
$a dendritické buňky $x imunologie $x metabolismus $x patologie $7 D003713
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a imunohistochemie $7 D007150
650    _2
$a imunofenotypizace $7 D016130
650    _2
$a Kaplanův-Meierův odhad $7 D053208
650    _2
$a tumor infiltrující lymfocyty $x imunologie $x metabolismus $x patologie $7 D016246
650    _2
$a lidé středního věku $7 D008875
650    _2
$a staging nádorů $7 D009367
650    _2
$a nádory vaječníků $x imunologie $x mortalita $x patologie $x terapie $7 D010051
650    _2
$a prognóza $7 D011379
650    _2
$a proporcionální rizikové modely $7 D016016
650    _2
$a T-lymfocyty - podskupiny $x imunologie $x metabolismus $x patologie $7 D016176
650    _2
$a nádorové mikroprostředí $x imunologie $7 D059016
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Kasikova, Lenka $u Department of Immunology, Charles University, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic. Sotio, Prague, Czech Republic.
700    1_
$a Hensler, Michal $u Sotio, Prague, Czech Republic.
700    1_
$a Skapa, Petr $u Department of Pathology and Molecular Medicine, Charles University, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic.
700    1_
$a Laco, Jan $u The Fingerland Department of Pathology, Charles University, Faculty of Medicine and University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
700    1_
$a Pecen, Ladislav $u Sotio, Prague, Czech Republic.
700    1_
$a Belicova, Lucie $u Sotio, Prague, Czech Republic.
700    1_
$a Praznovec, Ivan $u Department of Gynecology and Obstetrics, Charles University, Faculty of Medicine and University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
700    1_
$a Halaska, Michael J $u Department of Gynecology and Obstetrics, Charles University, 3rd Faculty of Medicine and University Hospital Kralovske Vinohrady, Prague, Czech Republic.
700    1_
$a Brtnicky, Tomas $u Department of Gynecology and Obstetrics, Charles University, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic.
700    1_
$a Salkova, Eva $u Department of Pathology and Molecular Medicine, Charles University, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic.
700    1_
$a Rob, Lukas $u Department of Gynecology and Obstetrics, Charles University, 3rd Faculty of Medicine and University Hospital Kralovske Vinohrady, Prague, Czech Republic.
700    1_
$a Kodet, Roman $u Department of Pathology and Molecular Medicine, Charles University, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic.
700    1_
$a Goc, Jeremy $u INSERM, U1138, Centre de Recherche des Cordeliers, Paris, France. Sorbonne Université, Paris, France. Université Paris Descartes/Paris V, Paris, France.
700    1_
$a Sautes-Fridman, Catherine $u INSERM, U1138, Centre de Recherche des Cordeliers, Paris, France. Sorbonne Université, Paris, France. Université Paris Descartes/Paris V, Paris, France.
700    1_
$a Fridman, Wolf Herman $u INSERM, U1138, Centre de Recherche des Cordeliers, Paris, France. Sorbonne Université, Paris, France. Université Paris Descartes/Paris V, Paris, France.
700    1_
$a Ryska, Ales $u The Fingerland Department of Pathology, Charles University, Faculty of Medicine and University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
700    1_
$a Galluzzi, Lorenzo $u Université Paris Descartes/Paris V, Paris, France. Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA. Sandra and Edward Meyer Cancer Center, New York, NY, USA.
700    1_
$a Spisek, Radek $u Department of Immunology, Charles University, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic. Sotio, Prague, Czech Republic.
700    1_
$a Fucikova, Jitka $u Department of Immunology, Charles University, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic. fucikova@sotio.com. Sotio, Prague, Czech Republic. fucikova@sotio.com.
773    0_
$w MED00201262 $t Journal for immunotherapy of cancer $x 2051-1426 $g Roč. 6, č. 1 (2018), s. 139
856    41
$u https://pubmed.ncbi.nlm.nih.gov/30526667 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20200109 $b ABA008
991    __
$a 20200116142140 $b ABA008
999    __
$a ok $b bmc $g 1483366 $s 1083770
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 6 $c 1 $d 139 $e 20181204 $i 2051-1426 $m Journal for immunotherapy of cancer $n J Immunother Cancer $x MED00201262
LZP    __
$a Pubmed-20200109

Najít záznam

Citační ukazatele

Možnosti archivace