-
Je něco špatně v tomto záznamu ?
Sensory profiles and immune-related expression patterns of patients with and without neuropathic pain after peripheral nerve lesion
M. Held, F. Karl, E. Vlckova, A. Rajdova, F. Escolano-Lozano, C. Stetter, R. Bharti, KU. Förstner, M. Leinders, L. Dušek, F. Birklein, J. Bednarik, C. Sommer, N. Üçeyler,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu srovnávací studie, časopisecké články, multicentrická studie, práce podpořená grantem
- MeSH
- dospělí MeSH
- exprese genu MeSH
- katastrofizace diagnóza genetika imunologie MeSH
- kohortové studie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mediátory zánětu metabolismus MeSH
- měření bolesti metody MeSH
- mladiství MeSH
- mladý dospělý MeSH
- nervová vlákna imunologie patologie MeSH
- neuralgie diagnóza genetika imunologie MeSH
- průřezové studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
In this multicenter cross-sectional study, we determined sensory profiles of patients with (NL-1) and without neuropathic pain (NL-0) after nerve lesion and assessed immune-related systemic gene expression. Patients and matched healthy controls filled in questionnaires and underwent neurological examination, neurophysiological studies, quantitative sensory testing, and blood withdrawal. Neuropathic pain was present in 67/95 (71%) patients (NL-1). Tactile hyperalgesia was the most prominent clinical sign in NL-1 patients (P < 0.05). Questionnaires showed an association between neuropathic pain and the presence of depression, anxiety, and catastrophizing (P < 0.05 to P < 0.01). Neuropathic pain was frequently accompanied by other chronic pain (P < 0.05). Quantitative sensory testing showed ipsilateral signs of small and large fiber impairment compared to the respective contralateral side, with elevated thermal and mechanical detection thresholds (P < 0.001 to P < 0.05) and lowered pressure pain threshold (P < 0.05). Also, more loss of function was found in patients with NL-1 compared to NL-0. Pain intensity was associated with mechanical hyperalgesia (P < 0.05 to P < 0.01). However, quantitative sensory testing did not detect or predict neuropathic pain. Gene expression of peptidylglycine α-amidating monooxygenase was higher in NL patients compared with healthy controls (NL-1, P < 0.01; NL-0, P < 0.001). Also, gene expression of tumor necrosis factor-α was higher in NL-1 patients compared with NL-0 (P < 0.05), and interleukin-1ß was higher, but IL-10 was lower in NL-1 patients compared with healthy controls (P < 0.05 each). Our study reveals that nerve lesion presents with small and large nerve fiber dysfunction, which may contribute to the presence and intensity of neuropathic pain and which is associated with a systemic proinflammatory pattern.
Department of Neurology University of Würzburg Würzburg Germany
Department of Neurosurgery University of Würzburg Würzburg Germany
Faculty of Medicine Institute of Biostatistics and Analyses Masaryk University Brno Czech Republic
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc20025636
- 003
- CZ-PrNML
- 005
- 20201222155321.0
- 007
- ta
- 008
- 201125s2019 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1097/j.pain.0000000000001623 $2 doi
- 035 __
- $a (PubMed)31145221
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Held, Melissa $u Department of Neurology, University of Würzburg, Würzburg, Germany.
- 245 10
- $a Sensory profiles and immune-related expression patterns of patients with and without neuropathic pain after peripheral nerve lesion / $c M. Held, F. Karl, E. Vlckova, A. Rajdova, F. Escolano-Lozano, C. Stetter, R. Bharti, KU. Förstner, M. Leinders, L. Dušek, F. Birklein, J. Bednarik, C. Sommer, N. Üçeyler,
- 520 9_
- $a In this multicenter cross-sectional study, we determined sensory profiles of patients with (NL-1) and without neuropathic pain (NL-0) after nerve lesion and assessed immune-related systemic gene expression. Patients and matched healthy controls filled in questionnaires and underwent neurological examination, neurophysiological studies, quantitative sensory testing, and blood withdrawal. Neuropathic pain was present in 67/95 (71%) patients (NL-1). Tactile hyperalgesia was the most prominent clinical sign in NL-1 patients (P < 0.05). Questionnaires showed an association between neuropathic pain and the presence of depression, anxiety, and catastrophizing (P < 0.05 to P < 0.01). Neuropathic pain was frequently accompanied by other chronic pain (P < 0.05). Quantitative sensory testing showed ipsilateral signs of small and large fiber impairment compared to the respective contralateral side, with elevated thermal and mechanical detection thresholds (P < 0.001 to P < 0.05) and lowered pressure pain threshold (P < 0.05). Also, more loss of function was found in patients with NL-1 compared to NL-0. Pain intensity was associated with mechanical hyperalgesia (P < 0.05 to P < 0.01). However, quantitative sensory testing did not detect or predict neuropathic pain. Gene expression of peptidylglycine α-amidating monooxygenase was higher in NL patients compared with healthy controls (NL-1, P < 0.01; NL-0, P < 0.001). Also, gene expression of tumor necrosis factor-α was higher in NL-1 patients compared with NL-0 (P < 0.05), and interleukin-1ß was higher, but IL-10 was lower in NL-1 patients compared with healthy controls (P < 0.05 each). Our study reveals that nerve lesion presents with small and large nerve fiber dysfunction, which may contribute to the presence and intensity of neuropathic pain and which is associated with a systemic proinflammatory pattern.
- 650 _2
- $a mladiství $7 D000293
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a senioři nad 80 let $7 D000369
- 650 _2
- $a katastrofizace $x diagnóza $x genetika $x imunologie $7 D058443
- 650 _2
- $a kohortové studie $7 D015331
- 650 _2
- $a průřezové studie $7 D003430
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a exprese genu $7 D015870
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mediátory zánětu $x metabolismus $7 D018836
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a nervová vlákna $x imunologie $x patologie $7 D009412
- 650 _2
- $a neuralgie $x diagnóza $x genetika $x imunologie $7 D009437
- 650 _2
- $a měření bolesti $x metody $7 D010147
- 650 _2
- $a mladý dospělý $7 D055815
- 655 _2
- $a srovnávací studie $7 D003160
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a multicentrická studie $7 D016448
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Karl, Franziska $u Department of Neurology, University of Würzburg, Würzburg, Germany.
- 700 1_
- $a Vlckova, Eva $u Department of Neurology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.
- 700 1_
- $a Rajdova, Aneta $u Department of Neurology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.
- 700 1_
- $a Escolano-Lozano, Fabiola $u Department of Neurology, University Medical Centre of the Johannes Gutenberg University Mainz, Mainz, Germany.
- 700 1_
- $a Stetter, Christian $u Department of Neurosurgery, University of Würzburg, Würzburg, Germany.
- 700 1_
- $a Bharti, Richa $u Institute for Molecular Infection Biology, University of Würzburg, Würzburg, Germany. Dr. Bharti is now with the Weihenstephan-Triesdorf University of Applied Sciences, TUM Campus, Straubing for Biotechnology and Sustainability, Straubing, Germany. Dr. Förstner is now with the ZB MED-Information Centre for Life Sciences, Cologne, Germany and TH Köln, Faculty of Information Science and Communication Studies, Cologne, Germany.
- 700 1_
- $a Förstner, Konrad U $u Institute for Molecular Infection Biology, University of Würzburg, Würzburg, Germany. Dr. Bharti is now with the Weihenstephan-Triesdorf University of Applied Sciences, TUM Campus, Straubing for Biotechnology and Sustainability, Straubing, Germany. Dr. Förstner is now with the ZB MED-Information Centre for Life Sciences, Cologne, Germany and TH Köln, Faculty of Information Science and Communication Studies, Cologne, Germany.
- 700 1_
- $a Leinders, Mathias $u Department of Neurology, University of Würzburg, Würzburg, Germany.
- 700 1_
- $a Dušek, Ladislav $u Faculty of Medicine, Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic.
- 700 1_
- $a Birklein, Frank $u Department of Neurology, University Medical Centre of the Johannes Gutenberg University Mainz, Mainz, Germany.
- 700 1_
- $a Bednarik, Josef $u Department of Neurology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.
- 700 1_
- $a Sommer, Claudia $u Department of Neurology, University of Würzburg, Würzburg, Germany.
- 700 1_
- $a Üçeyler, Nurcan $u Department of Neurology, University of Würzburg, Würzburg, Germany.
- 773 0_
- $w MED00003677 $t Pain $x 1872-6623 $g Roč. 160, č. 10 (2019), s. 2316-2327
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/31145221 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20201125 $b ABA008
- 991 __
- $a 20201222155316 $b ABA008
- 999 __
- $a ok $b bmc $g 1599781 $s 1116322
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2019 $b 160 $c 10 $d 2316-2327 $e - $i 1872-6623 $m Pain $n Pain $x MED00003677
- LZP __
- $a Pubmed-20201125
