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Molecular Mechanisms Underlying Hepatocellular Carcinoma Induction by Aberrant NRF2 Activation-Mediated Transcription Networks: Interaction of NRF2-KEAP1 Controls the Fate of Hepatocarcinogenesis
E. Haque, MR. Karim, A. Salam Teeli, M. Śmiech, P. Leszczynski, D. Winiarczyk, ED. Parvanov, AG. Atanasov, H. Taniguchi
Language English Country Switzerland
Document type Journal Article, Review
Grant support
2017/25/B/NZ5/02762
Narodowe Centrum Nauki
NLK
Free Medical Journals
from 2000
Freely Accessible Science Journals
from 2000
PubMed Central
from 2007
Europe PubMed Central
from 2007
ProQuest Central
from 2000-03-01
Open Access Digital Library
from 2000-01-01
Open Access Digital Library
from 2007-01-01
Health & Medicine (ProQuest)
from 2000-03-01
ROAD: Directory of Open Access Scholarly Resources
from 2000
PubMed
32751080
DOI
10.3390/ijms21155378
Knihovny.cz E-resources
- MeSH
- Transcriptional Activation * MeSH
- Survival Analysis MeSH
- NF-E2-Related Factor 2 genetics metabolism MeSH
- Gene Regulatory Networks MeSH
- Carcinoma, Hepatocellular diagnosis genetics mortality pathology MeSH
- Carcinogenesis genetics metabolism pathology MeSH
- Kelch-Like ECH-Associated Protein 1 genetics metabolism MeSH
- Humans MeSH
- Mutation MeSH
- Cell Line, Tumor MeSH
- Liver Neoplasms diagnosis genetics mortality pathology MeSH
- Oxidation-Reduction MeSH
- Oxidative Stress MeSH
- Prognosis MeSH
- Gene Expression Regulation, Neoplastic * MeSH
- Signal Transduction MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
NF-E2-related factor 2 (NRF2) is a basic leucine zipper transcription factor, a master regulator of redox homeostasis regulating a variety of genes for antioxidant and detoxification enzymes. NRF2 was, therefore, initially thought to protect the liver from oxidative stress. Recent studies, however, have revealed that mutations in NRF2 cause aberrant accumulation of NRF2 in the nucleus and exert the upregulation of NRF2 target genes. Moreover, among all molecular changes in hepatocellular carcinoma (HCC), NRF2 activation has been revealed as a more prominent pathway contributing to the progression of precancerous lesions to malignancy. Nevertheless, how its activation leads to poor prognosis in HCC patients remains unclear. In this review, we provide an overview of how aberrant activation of NRF2 triggers HCC development. We also summarize the emerging roles of other NRF family members in liver cancer development.
Department of Pharmacognosy University of Vienna 1090 Vienna Austria
Institute of Neurobiology Bulgarian Academy of Sciences 1113 Sofia Bulgaria
References provided by Crossref.org
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