Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Molecular Mechanisms Underlying Hepatocellular Carcinoma Induction by Aberrant NRF2 Activation-Mediated Transcription Networks: Interaction of NRF2-KEAP1 Controls the Fate of Hepatocarcinogenesis

E. Haque, MR. Karim, A. Salam Teeli, M. Śmiech, P. Leszczynski, D. Winiarczyk, ED. Parvanov, AG. Atanasov, H. Taniguchi

. 2020 ; 21 (15) : . [pub] 20200729

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc21012334

Grantová podpora
2017/25/B/NZ5/02762 Narodowe Centrum Nauki

NF-E2-related factor 2 (NRF2) is a basic leucine zipper transcription factor, a master regulator of redox homeostasis regulating a variety of genes for antioxidant and detoxification enzymes. NRF2 was, therefore, initially thought to protect the liver from oxidative stress. Recent studies, however, have revealed that mutations in NRF2 cause aberrant accumulation of NRF2 in the nucleus and exert the upregulation of NRF2 target genes. Moreover, among all molecular changes in hepatocellular carcinoma (HCC), NRF2 activation has been revealed as a more prominent pathway contributing to the progression of precancerous lesions to malignancy. Nevertheless, how its activation leads to poor prognosis in HCC patients remains unclear. In this review, we provide an overview of how aberrant activation of NRF2 triggers HCC development. We also summarize the emerging roles of other NRF family members in liver cancer development.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21012334
003      
CZ-PrNML
005      
20210507102636.0
007      
ta
008      
210420s2020 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/ijms21155378 $2 doi
035    __
$a (PubMed)32751080
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Haque, Effi $u Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, 05-552 Jastrzębiec, Poland
245    10
$a Molecular Mechanisms Underlying Hepatocellular Carcinoma Induction by Aberrant NRF2 Activation-Mediated Transcription Networks: Interaction of NRF2-KEAP1 Controls the Fate of Hepatocarcinogenesis / $c E. Haque, MR. Karim, A. Salam Teeli, M. Śmiech, P. Leszczynski, D. Winiarczyk, ED. Parvanov, AG. Atanasov, H. Taniguchi
520    9_
$a NF-E2-related factor 2 (NRF2) is a basic leucine zipper transcription factor, a master regulator of redox homeostasis regulating a variety of genes for antioxidant and detoxification enzymes. NRF2 was, therefore, initially thought to protect the liver from oxidative stress. Recent studies, however, have revealed that mutations in NRF2 cause aberrant accumulation of NRF2 in the nucleus and exert the upregulation of NRF2 target genes. Moreover, among all molecular changes in hepatocellular carcinoma (HCC), NRF2 activation has been revealed as a more prominent pathway contributing to the progression of precancerous lesions to malignancy. Nevertheless, how its activation leads to poor prognosis in HCC patients remains unclear. In this review, we provide an overview of how aberrant activation of NRF2 triggers HCC development. We also summarize the emerging roles of other NRF family members in liver cancer development.
650    _2
$a karcinogeneze $x genetika $x metabolismus $x patologie $7 D063646
650    _2
$a hepatocelulární karcinom $x diagnóza $x genetika $x mortalita $x patologie $7 D006528
650    _2
$a nádorové buněčné linie $7 D045744
650    12
$a regulace genové exprese u nádorů $7 D015972
650    _2
$a genové regulační sítě $7 D053263
650    _2
$a lidé $7 D006801
650    _2
$a KEAP-1 $x genetika $x metabolismus $7 D000072019
650    _2
$a nádory jater $x diagnóza $x genetika $x mortalita $x patologie $7 D008113
650    _2
$a mutace $7 D009154
650    _2
$a faktor 2 související s NF-E2 $x genetika $x metabolismus $7 D051267
650    _2
$a oxidace-redukce $7 D010084
650    _2
$a oxidační stres $7 D018384
650    _2
$a prognóza $7 D011379
650    _2
$a signální transdukce $7 D015398
650    _2
$a analýza přežití $7 D016019
650    12
$a aktivace transkripce $7 D015533
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Karim, M Rezaul $u Department of Biotechnology and Genetic Engineering, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh
700    1_
$a Salam Teeli, Aamir $u Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, 05-552 Jastrzębiec, Poland
700    1_
$a Śmiech, Magdalena $u Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, 05-552 Jastrzębiec, Poland
700    1_
$a Leszczynski, Paweł $u Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, 05-552 Jastrzębiec, Poland
700    1_
$a Winiarczyk, Dawid $u Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, 05-552 Jastrzębiec, Poland
700    1_
$a Parvanov, Emil D $u Division BIOCEV, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 420 Prague, Czech Republic
700    1_
$a Atanasov, Atanas G $u Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, 05-552 Jastrzębiec, Poland $u Ludwig Boltzmann Institute for Digital Health and Patient Safety, Medical University of Vienna, 1090 Vienna, Austria $u Institute of Neurobiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria $u Department of Pharmacognosy, University of Vienna, 1090 Vienna, Austria
700    1_
$a Taniguchi, Hiroaki $u Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, 05-552 Jastrzębiec, Poland
773    0_
$w MED00176142 $t International journal of molecular sciences $x 1422-0067 $g Roč. 21, č. 15 (2020)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/32751080 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20210420 $b ABA008
991    __
$a 20210507102635 $b ABA008
999    __
$a ok $b bmc $g 1650662 $s 1132713
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 21 $c 15 $e 20200729 $i 1422-0067 $m International journal of molecular sciences $n Int J Mol Sci $x MED00176142
GRA    __
$a 2017/25/B/NZ5/02762 $p Narodowe Centrum Nauki
LZP    __
$a Pubmed-20210420

Najít záznam

Citační ukazatele

Možnosti archivace